Members of the two-pore domain K+ channel (K 2P) family are increasingly recognized as
being potential targets for therapeutic drugs and could play a role in the diagnosis and …

Pharmacological targeting of ion channels has long been recognized as an attractive
strategy for the treatment of various diseases. Multiple sclerosis (MS) is an autoimmune …

The purpose of our study was to analyze abnormal neural regeneration activity in the cornea
through means of confocal microscopy in rheumatoid arthritis patients with concomitant dry …

Two-pore domain K2P K+ channels responsible for the background K+ conductance and the
resting membrane potential, are also finely regulated by a variety of chemical, physical and …

It remains largely unclear how thymocytes translate relative differences in T cell receptor
(TCR) signal strength into distinct developmental programs that drive the cell fate decisions …

K2P5. 1 channels (also called TASK‐2 or Kcnk5) have already been shown to be relevant in
the pathophysiology of autoimmune disease because they are known to be upregulated on …

Much progress has been made in understanding autoimmune channelopathies, but the
underlying pathogenic mechanisms are not always clear due to broad expression of some …

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects the
synovial joint, which leads to inflammation, loss of function, joint destruction, and disability …

Many functions of T lymphocytes are closely related to cell volume homeostasis and
regulation, which utilize a complex network of membrane channels for anions and cations …

The alkaline pH-activated, two-pore domain K+ channel K2P5. 1 (also known as
TASK2/KCNK5) plays an important role in maintaining the resting membrane potential, and …