The CNS under pathophysiologic attack—examining the role of K2P channels
P Ehling, M Cerina, T Budde, SG Meuth… - Pflügers Archiv-European …, 2015 - Springer
Members of the two-pore domain K+ channel (K 2P) family are increasingly recognized as
being potential targets for therapeutic drugs and could play a role in the diagnosis and …
being potential targets for therapeutic drugs and could play a role in the diagnosis and …
Targeting ion channels for the treatment of autoimmune neuroinflammation
S Bittner, SG Meuth - Therapeutic advances in neurological …, 2013 - journals.sagepub.com
Pharmacological targeting of ion channels has long been recognized as an attractive
strategy for the treatment of various diseases. Multiple sclerosis (MS) is an autoimmune …
strategy for the treatment of various diseases. Multiple sclerosis (MS) is an autoimmune …
Evidence of disruption in neural regeneration in dry eye secondary to rheumatoid arthritis
B Sonkodi, A Csorba, L Marsovszky, A Balog… - International Journal of …, 2023 - mdpi.com
The purpose of our study was to analyze abnormal neural regeneration activity in the cornea
through means of confocal microscopy in rheumatoid arthritis patients with concomitant dry …
through means of confocal microscopy in rheumatoid arthritis patients with concomitant dry …
Phosphatidylinositol (4,5)-bisphosphate dynamically regulates the K2P background K+ channel TASK-2
MI Niemeyer, LP Cid, M Paulais, J Teulon… - Scientific reports, 2017 - nature.com
Two-pore domain K2P K+ channels responsible for the background K+ conductance and the
resting membrane potential, are also finely regulated by a variety of chemical, physical and …
resting membrane potential, are also finely regulated by a variety of chemical, physical and …
K2P18.1 translates T cell receptor signals into thymic regulatory T cell development
T Ruck, S Bock, S Pfeuffer, CB Schroeter, D Cengiz… - Cell Research, 2022 - nature.com
It remains largely unclear how thymocytes translate relative differences in T cell receptor
(TCR) signal strength into distinct developmental programs that drive the cell fate decisions …
(TCR) signal strength into distinct developmental programs that drive the cell fate decisions …
14‐3‐3 Proteins regulate K2P5.1 surface expression on T lymphocytes
J Fernández‐Orth, P Ehling, T Ruck, S Pankratz… - Traffic, 2017 - Wiley Online Library
K2P5. 1 channels (also called TASK‐2 or Kcnk5) have already been shown to be relevant in
the pathophysiology of autoimmune disease because they are known to be upregulated on …
the pathophysiology of autoimmune disease because they are known to be upregulated on …
Regulation of neurovascular coupling in autoimmunity to water and ion channels
P Jukkola, C Gu - Autoimmunity reviews, 2015 - Elsevier
Much progress has been made in understanding autoimmune channelopathies, but the
underlying pathogenic mechanisms are not always clear due to broad expression of some …
underlying pathogenic mechanisms are not always clear due to broad expression of some …
Exploring the therapeutic opportunities of potassium channels for the treatment of rheumatoid arthritis
NE More, R Mandlik, S Zine, VS Gawali… - Frontiers in …, 2024 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects the
synovial joint, which leads to inflammation, loss of function, joint destruction, and disability …
synovial joint, which leads to inflammation, loss of function, joint destruction, and disability …
[HTML][HTML] Identification of two-pore domain potassium channels as potent modulators of osmotic volume regulation in human T lymphocytes
J Andronic, N Bobak, S Bittner, P Ehling… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Many functions of T lymphocytes are closely related to cell volume homeostasis and
regulation, which utilize a complex network of membrane channels for anions and cations …
regulation, which utilize a complex network of membrane channels for anions and cations …
Pathophysiological significance of the two-pore domain K+ channel K2P5.1 in splenic CD4+CD25− T cell subset from a chemically-induced murine inflammatory …
S Nakakura, M Matsui, A Sato, M Ishii, K Endo… - Frontiers in …, 2015 - frontiersin.org
The alkaline pH-activated, two-pore domain K+ channel K2P5. 1 (also known as
TASK2/KCNK5) plays an important role in maintaining the resting membrane potential, and …
TASK2/KCNK5) plays an important role in maintaining the resting membrane potential, and …