Generalized anxiety disorder (GAD), the most frequently diagnosed form of anxiety, is
usually treated by cognitive-behavioural approaches or medication; in particular …

BACKGROUND: Serotonin (5-HT) 1A and 2A receptors have been associated with
dysfunctional emotional processing biases in mood disorders. These receptors further …

Dehydroepiandrosterone (DHEA) is synthesized in the brain and several studies have
shown that this steroid is a modulator of synaptic transmission. The effect of DHEA, and its …

Diabetic neuropathic pain (DNP) is a diabetes complication experienced by many patients.
Ventrolateral periaqueductal gray (vlPAG) neurons are essential mediators of the …

Anxiety disorders often co-occur with alcohol use disorders, but the mechanisms underlying
this comorbidity remain elusive. Previously, we reported that rats withdrawn from chronic …

Motor function and anxiety-like responses are easily quantifiable in zebrafish, a novel model
organism for behavioral pharmacology. Activation of serotonin receptors through the use of …

The vesicular monoamine transporter type 2 gene (VMAT2) has a crucial role in the storage
and synaptic release of all monoamines, including serotonin (5-HT). To evaluate the specific …

Serotonin 2C receptors are G protein‐coupled receptors expressed by GABAergic,
glutamatergic, and dopaminergic neurons. Anatomically, they are present in various brain …

Serotonin (5-HT) receptors are found throughout central and peripheral nervous systems,
mainly in brain regions involved in the neurobiology of anxiety and depression. 5-HT …

Abstract Serotonin 5-hydroxytryptamine (5-HT) is a key neurotransmitter for the modulation
and/or regulation of numerous physiological processes and psychiatric disorders (eg …