Introduction: This paper reviews the risk of thrombosis with use of different types of hormonal
contraception in women of different ages. Areas covered: Combined hormonal …

Hormonal contraceptives have been on the market for over fifty years and, while their
formulations have changed, the basic mechanism of action has remained the same. During …

We compared thrombophilia and hypofibrinolysis in 6 men with Klinefelter syndrome (KS),
without previously known familial thrombophilia, who had sustained deep venous …

Background RMND1 is a nuclear gene needed for proper function of mitochondria. A
pathogenic gene will cause multiple oxidative phosphorylation defects. A renal phenotype …

A case of a patient with severe factor XI (FXI) deficiency who presented for her seventh labor
and delivery is presented. The nature of FXI deficiency, its prevalence, and issues related to …

We report three heterozygous PROS1 mutations that caused type I protein S deficiency in
three unrelated Chinese families. We measured protein S activity and antigen levels for all …

Background In patients hospitalized over a 4 year period for pulmonary embolism (PE), we
assessed relationships of testosterone (TT) and estrogen therapy (ET) anteceding PE in …

Direct oral anticoagulants (DOACs) are widely used in several indications, but data on their
efficacy and safety in individuals affected by severe inherited thrombophilia, yet without any …

Venous thromboembolism (VTE) is a chronic illness that includes pulmonary embolism (PE)
and deep vein thrombosis (DVT), and many risk factors are associated. Anticoagulation …

Inherited thrombophilia is a blood clotting disorder caused by genetic mutations of specific
coagulation plasma factors. It is a well-established predisposing factor for venous as well as …