[HTML][HTML] Barrel cortex function

D Feldmeyer, M Brecht, F Helmchen… - Progress in …, 2013 - Elsevier
Neocortex, the neuronal structure at the base of the remarkable cognitive skills of mammals,
is a layered sheet of neuronal tissue composed of juxtaposed and interconnected columns …

The developmental stages of synaptic plasticity

C Lohmann, HW Kessels - The Journal of physiology, 2014 - Wiley Online Library
The brain is programmed to drive behaviour by precisely wiring the appropriate neuronal
circuits. Wiring and rewiring of neuronal circuits largely depends on the orchestrated …

Early postnatal development of pyramidal neurons across layers of the mouse medial prefrontal cortex

T Kroon, E van Hugte, L van Linge, HD Mansvelder… - Scientific reports, 2019 - nature.com
Mammalian neocortex is a highly layered structure. Each layer is populated by distinct
subtypes of principal cells that are born at different times during development. While the …

Rethinking schizophrenia in the context of normal neurodevelopment

VS Catts, SJ Fung, LE Long, D Joshi… - Frontiers in cellular …, 2013 - frontiersin.org
The schizophrenia brain is differentiated from the normal brain by subtle changes, with
significant overlap in measures between normal and disease states. For the past 25 years …

The low synaptic release probability in vivo

JGG Borst - Trends in neurosciences, 2010 - cell.com
The release probability, the average probability that an active zone of a presynaptic terminal
releases one or more vesicles following an action potential, is tightly regulated …

Specificity of synaptic connectivity between layer 1 inhibitory interneurons and layer 2/3 pyramidal neurons in the rat neocortex

C Wozny, SR Williams - Cerebral cortex, 2011 - academic.oup.com
Understanding the structure and function of the neocortical microcircuit requires a
description of the synaptic connectivity between identified neuronal populations. Here, we …

Hyperconnectivity and slow synapses during early development of medial prefrontal cortex in a mouse model for mental retardation and autism

G Testa-Silva, A Loebel, M Giugliano… - Cerebral …, 2012 - academic.oup.com
Neuronal theories of neurodevelopmental disorders (NDDs) of autism and mental
retardation propose that abnormal connectivity underlies deficits in attentional processing …

Decreasing-rate pruning optimizes the construction of efficient and robust distributed networks

S Navlakha, AL Barth, Z Bar-Joseph - PLoS computational biology, 2015 - journals.plos.org
Robust, efficient, and low-cost networks are advantageous in both biological and
engineered systems. During neural network development in the brain, synapses are …

The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period

B Jiang, S Huang, R de Pasquale, D Millman, L Song… - Neuron, 2010 - cell.com
Endocannabinoids are widely regarded as negative modulators of presynaptic release.
Here, we present evidence that in visual cortex endocannabinoids are crucial for the …

Developmental maturation of excitation and inhibition balance in principal neurons across four layers of somatosensory cortex

Z Zhang, YY Jiao, QQ Sun - Neuroscience, 2011 - Elsevier
In adult cortices, the ratio of excitatory and inhibitory conductances (E/I ratio) is presumably
balanced across a wide range of stimulus conditions. However, it is unknown how the E/I …