Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

Immunohistochemistry plays an indispensable role in accurate diagnosis of malignant
mesothelioma, particularly in morphologically challenging cases and in biopsy and cytology …

Bisulfite sequencing has been the gold standard for mapping DNA modifications including 5-
methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) for decades,,–. However, this …

Hydroxymethylcytosine (5hmC) is an important mammalian DNA epigenetic modification
that has been linked to gene regulation and cancer pathogenesis. Here we explored the …

The TET enzymes are members of the 2-oxoglutarate-dependent dioxygenase family and
comprise three isoenzymes in humans: TETs 1–3. These TETs convert 5-methylcytosine to 5 …

Simple Summary Colorectal cancer (CRC) is one of the most prevalent cancers worldwide.
Due to the absence of specific early symptoms, most of CRC patients are often diagnosed at …

In the last years, liquid biopsy gained increasing clinical relevance for detecting and
monitoring several cancer types, being minimally invasive, highly informative and replicable …

Background Cirrhosis is a recognized risk factor for developing hepatocellular carcinoma
(HCC). Few studies have reported the expression profile of circRNAs in HCC samples …

Methylation analysis of circulating cell-free DNA (cirDNA), as a liquid biopsy, has a
significant potential to advance the detection, prognosis, and treatment of cancer, as well as …

Glioblastomas exhibit widespread molecular alterations including a highly distorted
epigenome. Here, we resolve genome-wide 5-methylcytosine and 5-hydroxymethylcytosine …