Health benefits of polyphenols: A concise review
Plants produce polyphenols, which are considered highly essential functional foods in our
diet. They are classified into several groups according to their diverse chemical structures …
diet. They are classified into several groups according to their diverse chemical structures …
Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer
Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …
one of the most frequently dysregulated signaling pathways observed in cancer patients that …
A comprehensive review on MAPK: a promising therapeutic target in cancer
The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch
from extracellular signals to intracellular responses. Alterations of signaling cascades are …
from extracellular signals to intracellular responses. Alterations of signaling cascades are …
Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway
X Zhang, S Wang, H Wang, J Cao, X Huang, Z Chen… - Molecular cancer, 2019 - Springer
Background CircRNA has emerged as a new non-coding RNA that plays crucial roles in
tumour initiation and development.'MiRNA sponge'is the most reported role played by …
tumour initiation and development.'MiRNA sponge'is the most reported role played by …
Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy
Abstract The phosphatidylinositol 3-kinase (PI3K)-Akt and the mammalian target of
rapamycin (mTOR) represent two vital intracellular signaling pathways, which are …
rapamycin (mTOR) represent two vital intracellular signaling pathways, which are …
Cuproptosis-associated lncRNA establishes new prognostic profile and predicts immunotherapy response in clear cell renal cell carcinoma
S Xu, D Liu, T Chang, X Wen, S Ma, G Sun… - Frontiers in …, 2022 - frontiersin.org
Background: Clear cell renal cell carcinoma (ccRCC) accounts for 80% of all kidney cancers
and has a poor prognosis. Recent studies have shown that copper-dependent, regulated …
and has a poor prognosis. Recent studies have shown that copper-dependent, regulated …
Targeting the PI3K pathway in cancer: are we making headway?
F Janku, TA Yap, F Meric-Bernstam - Nature reviews Clinical oncology, 2018 - nature.com
Abstract The PI3K–AKT–mTOR pathway is one of the most frequently dysregulated
pathways in cancer and, consequently, more than 40 compounds that target key …
pathways in cancer and, consequently, more than 40 compounds that target key …
The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances
Metformin is a widely used drug in today's prescriptions by physicians due to its specific
effects in treating and curing type II diabetes. Diabetes is a common disease that may occur …
effects in treating and curing type II diabetes. Diabetes is a common disease that may occur …
Tanshinone I attenuates the malignant biological properties of ovarian cancer by inducing apoptosis and autophagy via the inactivation of PI3K/AKT/mTOR pathway
J Zhou, Y Jiang, H Chen, Y Wu, L Zhang - Cell proliferation, 2020 - Wiley Online Library
Abstract Objectives Tanshinone I (Tan‐I) is one of the vital fatsoluble monomer components,
which extracted from Chinese medicinal herb Salvia miltiorrhiza Bunge. It has been shown …
which extracted from Chinese medicinal herb Salvia miltiorrhiza Bunge. It has been shown …
PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives
The protein kinases regulate cellular functions such as transcription, translation,
proliferation, growth and survival by the process of phosphorylation. Over activation of …
proliferation, growth and survival by the process of phosphorylation. Over activation of …