[HTML][HTML] Exploring the antibacterial, antidiabetic, and anticancer potential of Mentha arvensis extract through in-silico and in-vitro analysis
Background Mentha arvensis has been utilized in diverse traditional medicines as an
antidiabetic, anticarcinogenic, antiallergic, antifungal, and antibacterial agent. In this work …
antidiabetic, anticarcinogenic, antiallergic, antifungal, and antibacterial agent. In this work …
[HTML][HTML] Consensus docking aid to model the activity of an inhibitor of DNA methyltransferase 1 inspired by de novo design
DL Prado-Romero, A Gómez-García… - Frontiers in Drug …, 2023 - frontiersin.org
The structure-activity relationships data available in public databases of inhibitors of DNA
methyltransferases (DNMTs), families of epigenetic targets, plus the structural information of …
methyltransferases (DNMTs), families of epigenetic targets, plus the structural information of …
[HTML][HTML] Chemoinformatics and machine learning techniques to identify novel inhibitors of the lemur tyrosine kinase-3 receptor involved in breast cancer
F Alrumaihi - Frontiers in Molecular Biosciences, 2024 - frontiersin.org
Breast cancer is still the largest cause of cancer death in women, and around 70% of
primary breast cancer patients are estrogen receptor (ER)-positive, which is the most …
primary breast cancer patients are estrogen receptor (ER)-positive, which is the most …
Network pharmacology and molecular dynamic simulation integrated strategy for the screening of active components and mechanisms of phytochemicals from Datura …
MA Alamri, M Tahir ul Qamar - Journal of Biomolecular Structure …, 2024 - Taylor & Francis
Alzheimer's disease (AD) ranks as the most prevalent neurodegenerative disorder with
dementia and it accounts for more than 70% of all cases. Despite extensive reporting on the …
dementia and it accounts for more than 70% of all cases. Despite extensive reporting on the …
Exploring therapeutic targets and drug candidates for obesity: a combined network pharmacology, bioinformatics approach
The remarkably high prevalence of obesity in Saudi Arabia reflects a global epidemic
demanding urgent attention due to its associated health risks. The integration of traditional …
demanding urgent attention due to its associated health risks. The integration of traditional …
Identification of promising inhibitors against breast cancer disease by targeting NUDIX hydrolase 5 (NUDT5) biomolecule
NM Almansour - Journal of Biomolecular Structure and Dynamics, 2023 - Taylor & Francis
It is well documented that NUDT5 enzyme inhibition in breast cancer cell lines arrest cancer
cells growth, invasiveness and migration. The NUDT5 enzyme enhances breast cancer …
cells growth, invasiveness and migration. The NUDT5 enzyme enhances breast cancer …
[HTML][HTML] Decitabine/paclitaxel co-delivery systems modified with anti-PD-L1 antibodies mediate chemoimmunotherapy for Triple negative breast cancer
Y He, Q Hu, L Wang, C Chen - Materials & Design, 2024 - Elsevier
Triple-negative breast cancer (TNBC) is one of the major clinical problems to be solved
urgently, because of its high malignancy, poor targeted therapy effect and easy occurrence …
urgently, because of its high malignancy, poor targeted therapy effect and easy occurrence …
[HTML][HTML] Integrated virtual screening, molecular modeling and machine learning approaches revealed potential natural inhibitors for epilepsy
FF Alshehri - Saudi Pharmaceutical Journal, 2023 - Elsevier
Epilepsy, a prevalent chronic disorder of the central nervous system, is typified by recurrent
seizures. Present treatments predominantly offer symptomatic relief by managing seizures …
seizures. Present treatments predominantly offer symptomatic relief by managing seizures …