[HTML][HTML] Molecular insight into pentraxin-3: Update advances in innate immunity, inflammation, tissue remodeling, diseases, and drug role
Abstract Pentraxin-3 (PTX3) is the prototype of the long pentraxin subfamily, an acute-phase
protein consisting of a C-terminal pentraxin domain and a unique N-terminal domain. PTX3 …
protein consisting of a C-terminal pentraxin domain and a unique N-terminal domain. PTX3 …
Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment
Primary tumors are drivers of pre-metastatic niche formation, but the coordination by the
secondary organ toward metastatic dissemination is underappreciated. Here, by single-cell …
secondary organ toward metastatic dissemination is underappreciated. Here, by single-cell …
PTX3 regulation of inflammation, hemostatic response, tissue repair, and resolution of fibrosis favors a role in limiting idiopathic pulmonary fibrosis
PTX3 is a soluble pattern recognition molecule (PRM) belonging to the humoral innate
immune system, rapidly produced at inflammatory sites by phagocytes and stromal cells in …
immune system, rapidly produced at inflammatory sites by phagocytes and stromal cells in …
A single-cell transcriptional roadmap of the mouse and human lymph node lymphatic vasculature
Single-cell transcriptomics promise to revolutionize our understanding of the vasculature.
Emerging computational methods applied to high-dimensional single-cell data allow …
Emerging computational methods applied to high-dimensional single-cell data allow …
Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties
Grafting of neural stem cells (NSCs) derived from human induced pluripotent stem cells
(hiPSCs) has shown promise for brain repair after injury or disease, but safety issues have …
(hiPSCs) has shown promise for brain repair after injury or disease, but safety issues have …
[HTML][HTML] Transcriptional space-time mapping identifies concerted immune and stromal cell patterns and gene programs in wound healing and cancer
Tissue repair responses in metazoans are highly coordinated by different cell types over
space and time. However, comprehensive single-cell-based characterization covering this …
space and time. However, comprehensive single-cell-based characterization covering this …
Chemotherapy-induced upregulation of small extracellular vesicle-associated PTX3 accelerates breast cancer metastasis
Although neoadjuvant chemotherapy is a standard component of breast cancer treatment,
recent evidence suggests that chemotherapeutic drugs can promote metastasis through …
recent evidence suggests that chemotherapeutic drugs can promote metastasis through …
Vasculature atrophy causes a stiffened microenvironment that augments epidermal stem cell differentiation in aged skin
Stem cell loss causes tissue deterioration associated with aging. The accumulation of
genomic and oxidative stress-induced DNA damage is an intrinsic cue for stem cell loss,; …
genomic and oxidative stress-induced DNA damage is an intrinsic cue for stem cell loss,; …
PacBio Iso-Seq improves the rainbow trout genome annotation and identifies alternative splicing associated with economically important phenotypes
Rainbow trout is an important model organism that has received concerted international
efforts to study the transcriptome. For this purpose, short-read sequencing has been …
efforts to study the transcriptome. For this purpose, short-read sequencing has been …
Structural insights into the biological functions of the long pentraxin PTX3
AM Massimino, FE Colella, B Bottazzi… - Frontiers in …, 2023 - frontiersin.org
Soluble pattern recognition molecules (PRMs) are a heterogenous group of proteins that
recognize pathogen-and danger-associated molecular patterns (PAMPs and DAMPs …
recognize pathogen-and danger-associated molecular patterns (PAMPs and DAMPs …