The neurokinin 1 receptor (NK‐1R) is the main receptor for the tachykinin family of peptides.
Substance P (SP) is the major mammalian ligand and the one with the highest affinity. SP is …

The G protein–coupled receptor (GPCR), neurokinin‐1 receptor (NK1R), and its preferred
ligand, substance P (SP), are reviewed in relationship to the immune system and selected …

Neurogenic inflammation encompasses the release of neuropeptides from airway nerves
leading to inflammatory effects. This neurogenic inflammatory response of the airways can …

The mammalian tachykinins are a family of peptides that, until recently, has included
substance P (SP), neurokinin A and neurokinin B. Since, the discovery of a third …

The first report demonstrating the therapeutic efficacy of an orally applied neurokinin-1
(NK1) receptor antagonist in depression was published 10 years ago. Although there were …

The tachykinins substance P and neurokinin A are present in human airways, in sensory
nerves and immune cells. Tachykinins can be recovered from the airways after inhalation of …

There is an expanding repertoire of mammalian tachykinins produced by a variety of
tachykinin genes, gene splicing events and peptide processing. Novel tachykinin-binding …

The nervous system mediates key airway protective behaviors, including cough, mucus
secretion, and airway smooth muscle contraction. Thus, its involvement and potential …

ERBB receptor transmodulation by heterologous G-protein–coupled receptors (GPCR)
generates functional diversity in signal transduction. Tachykinins are neuropeptides and …

One important, however, poorly understood, concept of Traditional Chinese Medicine (TCM)
is that of hot, cold, and neutral nature of its bioactive principles. To advance the field, in this …