MEN15596, a novel nonpeptide tachykinin NK2 receptor antagonist

C Cialdai, M Tramontana, R Patacchini, A Lecci… - European journal of …, 2006 - Elsevier
The pharmacological profile of MEN15596 or (6-methyl-benzo [b] thiophene-2-carboxylic
acid [1-(2-phenyl-1R-{[1-(tetrahydropyran-4-ylmethyl)-piperidin-4-ylmethyl]-carbamoyl} …

Acute NK1 receptor antagonist administration affects reward incentive anticipation processing in healthy volunteers

K Saji, Y Ikeda, W Kim, Y Shingai… - International Journal …, 2013 - academic.oup.com
The primary brain structures of reward processing are mainly situated in the mid-brain
dopamine system. The nucleus accumbens (NAc) receives dopaminergic projections from …

Bovine respiratory syncytial virus lacking the virokinin or with a mutation in furin cleavage site RA(R/K)R109 induces less pulmonary inflammation without impeding …

JF Valarcher, J Furze, SG Wyld… - Journal of general …, 2006 - microbiologyresearch.org
The BRSV fusion (F) protein is cleaved at two furin consensus sequence sites, resulting in
the generation of disulphide-linked F1 and F2 subunits and the release of an intervening …

[PDF][PDF] ROLE OF AFFERENT NERVES AND SENSORY PEPTIDES

J Biernat, WW Pawlik, R Sendur… - Journal of physiology …, 2005 - jpp.krakow.pl
Intrahepatic arteries are richly innervated by both adrenergic and sensory vanilloidsensitive
(capsaicin-sensitive) fibers. Stimulation of capsaicin sensitive fibers has been shown to …

Association of genetic variants in tachykinins pathway genes with colorectal cancer risk

Y Yu, Y Pan, M Jin, M Zhang, S Zhang, Q Li… - International journal of …, 2012 - Springer
Purpose This study aims to explore the associations of polymorphisms in tachykinin,
precursor 1 (TAC1), tachykinin receptor 1 (T ACR1), and tachykinin receptor 2 (TACR2) …

[PDF][PDF] Tachykinin receptors and gastrointestinal motility: focus on humans.

A Lecci, M Altamura, A Capriati… - European Review for …, 2008 - europeanreview.org
Peptides of the tachykinin (TK) family were first discovered in the gastrointestinal tissue
about 75 years ago and supposed to be involved in gastrointestinal (GI) motility. This …

[PDF][PDF] The rs3771863 single nucleotide polymorphism of the TACR1 gene is associated to a lower risk of sicca syndrome in fibromyalgia patients

L Rodriguez-Rodriguez, J Ramon Lamas… - Clin Exp …, 2015 - academia.edu
Objective. Fibromyalgia (FM) has been associated with affective spectrum disorders and
other chronic pain disorders, which tend to co-occur in individuals and co-aggregate among …

Regulation of the stimulant actions of neurokinin a and human hemokinin-1 on the human uterus: a comparison with histamine

JN Pennefather, E Patak, S Ziccone… - Biology of …, 2006 - academic.oup.com
Regulation of the contractile effects of tachykinins and histamine on the human uterus was
investigated with biopsy sections of the outer myometrial layer. The effects of neurokinin A …

[HTML][HTML] Нейроопосредованные и эндотелийзависимые механизмы формирования хронической обструктивной болезни легких

ТА Бродская, ВА Невзорова… - Терапевтический …, 2020 - cyberleninka.ru
Эмфизема-одно из основных проявлений хронической обструктивной болезни легких
(ХОБЛ), а курение-один из наиболее значимых факторов риска. Результаты …

Recurrent major depressive disorder: imbalance of neurokinin (NK)-1 and NK-2 receptor expression in monocytes

C Bardelli, A Amoruso, E Manzetti, LG Fresu… - Pharmacological …, 2013 - Elsevier
Increasing evidence suggests that tachykinins are involved in the control of different
pathological conditions, including psychiatric disorders. In this study we evaluated the …