Abstract Neurokinin-1 receptor (NK1R), a G-protein coupled receptor involved in diverse
functions including pain and inflammation, has two putative N-linked glycosylation sites, at …

What the reader will gain: Chemically diverse non-peptide NK1 receptor antagonists have
been identified since the discovery of CP-96,345 by Pfizer in 1991. Representative …

The skin contains a vital mediator of pro-inflammatory mechanisms called substance P (SP).
SP targets various cells associated with the cutaneous induction of pruritus, for example …

Substance P (SP) is not only an important mediator for neuroimmune mechanisms, but a
causal agent involved in maintaining pruritus in the central nervous system (CNS) and skin …

Hay momentos en la vida en los que decidir marcar nuevos retos personales y
profesionales pueden hacer de ti una persona nueva, más valiente, un constructor de la …

The Na+-K+ ATPase is an enzyme responsible for the active transport of Na+ and K+ in most
eukaryotic cells. The aim of the present study was to determine the effect of Tachykinin …

Changes in the fluidity of membrane lipids are known to occur during aging and by lipid
peroxidation. It is well documented that the fluidity state of the lipid phase in a membrane is …

Chronic pain is a major healthcare concern that directly affects over one hundred million
people in the United States alone. While current treatment options like opioids and NSAIDs …

Aging is the leading risk factor for neurodegenerative diseases and oxidative stress involved
in the pathophysiology of these diseases. These changes increase during menopausal …

The brain experiences structural, molecular and functional alterations during aging. In aging
brain tissue, the oxidative stress increases due to decreased activity of antioxidant enzymes …