Recently, in the field of cancer treatment, the paradigm has changed to immunotherapy that
activates the immune system to induce cancer attacks. Among them, immune checkpoint …

Immune checkpoint blockade therapy has become a major weapon in fighting cancer.
Antibody drugs, such as anti-PD-1 and anti-PD-L1, demonstrate obvious advantages such …

Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …

Cells encode information in the sequence of biopolymers, such as nucleic acids, proteins,
and glycans. Although glycans are essential to all living organisms, surprisingly little is …

Protein post-translational modifications (PTMs) profoundly influence protein functions and
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …

The C-type lectin receptor Dectin-1 was originally described as the β-glucan receptor
expressed in myeloid cells, with crucial functions in antifungal responses. However, over …

The lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a secreted,
hyperglycosylated protein expressed by the majority of human cells. It was first identified as …

N-linked glycosylation is one of the most abundant posttranslational modifications of
membrane-bound proteins in eukaryotes and affects a number of biological activities …

Glycans are major constituents of extracellular vesicles (EVs). Alterations in the
glycosylation pathway are a common feature of cancer cells, which gives rise to de novo or …

Molecularly imprinted polymers (MIPs) are currently widely used and further developed for
biological applications. The MIP synthesis procedure is a key process, and a wide variety of …