Antioxidative 0-dimensional Nanodrugs Overcomes Obstacles in AKI Antioxidant Therapy

Y Yang, Y Nan, Q Chen, Z Xiao, H Zhang… - Journal of Materials …, 2023 - pubs.rsc.org
Acute kidney injury (AKI) is a commonly encountered syndrome associated with various
aetiologies and pathophysiological processes leading to enormous health risks and …

Precisely inhibiting excessive intestinal epithelial cell apoptosis to efficiently treat inflammatory bowel disease with oral pifithrin‐α embedded nanomedicine (OPEN)

M Wang, Q Huang, M Liu, T Zhao, X Song… - Advanced …, 2023 - Wiley Online Library
The increased incidence of inflammatory bowel disease (IBD) has seriously affected the life
quality of patients. IBD develops due to excessive intestinal epithelial cell (IEC) apoptosis …

H2S‐Releasing Versatile Montmorillonite Nanoformulation Trilogically Renovates the Gut Microenvironment for Inflammatory Bowel Disease Modulation

T Jin, H Lu, Q Zhou, D Chen, Y Zeng, J Shi… - Advanced …, 2024 - Wiley Online Library
Abnormal activation of the intestinal mucosal immune system, resulting from damage to the
intestinal mucosal barrier and extensive invasion by pathogens, contributes to the …

A Gas Therapy Strategy for Intestinal Flora Regulation and Colitis Treatment by Nanogel‐Based Multistage NO Delivery Microcapsules

YJ Fu, X Zhao, LY Wang, K Li, N Jiang… - Advanced …, 2024 - Wiley Online Library
Current approaches to treating inflammatory bowel disease focus on the suppression of
overactive immune responses, the removal of reactive intestinal oxygen species, and …

Nitric Oxide‐Based Nanomedicines for Conquering TME Fortress: Say “NO” to Insufficient Tumor Treatment

Y Xiang, Q Chen, Y Nan, M Liu, Z Xiao… - Advanced Functional …, 2024 - Wiley Online Library
Almost all cancer treatments are significantly limited by the strong tumor microenvironment
(TME) fortress formed by abnormal vasculature, dense extracellular matrix (ECM), multidrug …

Metabolic nanoregulator remodels gut microenvironment for treatment of inflammatory bowel disease

T Xu, X Ning, J Wu, Q Wang, Z Wang, Z Chen, X Tang… - ACS …, 2024 - ACS Publications
Inflammatory bowel disease (IBD) is strongly related to the occurrence of accumulation of
toxic reactive oxygen species (ROS), inflammation of the mucosa, and an imbalance of …

Anticoagulant therapy without bleeding: A novel molybdenum‐based nanodots alleviate lethal coagulation in bacterial sepsis by inhibiting ROS‐facilitated caspase …

C Yuan, Q Xiao, Q Chen, Q Huang, K Ai, X Yang - SmartMat, 2024 - Wiley Online Library
Sepsis is a leading cause of death worldwide. This syndrome is commonly accompanied by
overactivation of coagulation, excessive reactive oxygen species (ROS), and inflammatory …

Enhanced Codelivery of Gefitinib and Azacitidine for Treatment of Metastatic-Resistant Lung Cancer Using Biodegradable Lipid Nanoparticles

EM Elzayat, AY Sherif, FA Nasr, MW Attwa, DH Alshora… - Materials, 2023 - mdpi.com
Lung cancer is a formidable challenge in clinical practice owing to its metastatic nature and
resistance to conventional treatments. The codelivery of anticancer agents offers a potential …

Probiotics Armed with In Situ Mineralized Nanocatalysts and Targeted Biocoatings for Multipronged Treatment of Inflammatory Bowel Disease

T Chen, W Meng, Y Li, X Li, X Yu, J Qi, D Ding… - Nano Letters, 2024 - ACS Publications
While oral probiotics show promise in treating inflammatory bowel disease, the primary
challenge lies in sustaining their activity and retention within the inflamed gastrointestinal …

Highly Crystalline Copper Aluminum-Layered Double Hydroxides with Intrinsic Fenton-Like Catalytic Activity for Robust Oral Health Management

D Luo, X Liu, S Dai, J Yi, N Tang, Y Cai, X Bao… - Inorganic …, 2024 - ACS Publications
As the main challenge of dental healthcare, oral infectious diseases are highly associated
with the colonization of pathogenic microbes. However, current antibacterial treatments in …