Electron–microscopic (EM) analysis preceded crystallographic analysis [1, 2] of Igs by over a
decade and was for a time the only direct way of analyzing their 3–D molecular structure …

Various native and hinge-modified forms of Ig with identical Ids were reacted with an anti-Id
mAb, and the resultant immune complexes were analyzed by negative stain immunoelectron …

A central tenet of the current understanding of the relationship between Ab structure and
function is that the variable region domain is solely responsible for Ag specificity. However …

Treatment of normal polyclonal human IgG and of F (ab′) 2fragments of IgG with 6.0 M
urea, 1.3 M sodium thiocyanate or with acidic buffers (pH2. 0), resulted in a dramatic and …

A dual-specific, tetravalent immunoglobulin G-like molecule, termed dual variable domain
immunoglobulin (DVD-Ig™), is engineered to block two targets. Flexibility modulates Fc …

Molecular recognition between a receptor and a ligand requires a certain level of flexibility in
macromolecules. In this study, we aimed at analyzing the conformational variability of …

BACKGROUND Different strategies can be used to improve the tumor: non‐tumor ratio of
radiolabeled antibodies in immunotargeting. One approach is to use secondary antibodies …

2G12 is one of only a few cloned antibodies with broadly neutralizing specificity to HIV-1
envelope proteins. Crystallographic and electron microscopic (EM) data showed that the …

The functional valency of a monoclonal antibody (mAb) has important influences on such
things as antigen avidity, Fc-mediated immune effector functions, and clearance of immune …

The cell surface co-stimulatory protein CD154 (CD40L) is a target for monoclonal antibody
(mAb) inhibitors of T-cell mediated immune diseases. This protein, like most other members …