[HTML][HTML] Advances in the immunomodulatory properties of glycoantigens in cancer
V da Costa, T Freire - Cancers, 2022 - mdpi.com
Simple Summary This work reviews the role of aberrant glycosylation in cancer cells during
tumour growth and spreading, as well as in immune evasion. The interaction of tumour …
tumour growth and spreading, as well as in immune evasion. The interaction of tumour …
Solvent model benchmark for molecular dynamics of glycosaminoglycans
M Marcisz, SA Samsonov - Journal of chemical information and …, 2023 - ACS Publications
In computational studies of glycosaminoglycans (GAGs), a group of anionic, periodic linear
polysaccharides, so far there has been very little discussion about the role of solvent models …
polysaccharides, so far there has been very little discussion about the role of solvent models …
[HTML][HTML] Biomaterial considerations for ovarian cancer models
M Kramer, A Criswell, MK Sewell-Loftin - Frontiers in Materials, 2023 - frontiersin.org
Ovarian cancer is the 5th most common and the deadliest gynecological cancer, with a 5-
year survival rate of less than 50 percent. Most deaths due to ovarian cancer are caused by …
year survival rate of less than 50 percent. Most deaths due to ovarian cancer are caused by …
[HTML][HTML] Altered glycosylation in progression and management of bladder cancer
M Wilczak, M Surman, M Przybyło - Molecules, 2023 - mdpi.com
Bladder cancer (BC) is the 10th most common malignancy worldwide, with an estimated
573,000 new cases and 213,000 deaths in 2020. Available therapeutic approaches are still …
573,000 new cases and 213,000 deaths in 2020. Available therapeutic approaches are still …
[HTML][HTML] Heparan sulfate glycosaminoglycans:(Un) Expected allies in cancer clinical management
I Faria-Ramos, J Poças, C Marques, J Santos-Antunes… - Biomolecules, 2021 - mdpi.com
In an era when cancer glycobiology research is exponentially growing, we are witnessing a
progressive translation of the major scientific findings to the clinical practice with the …
progressive translation of the major scientific findings to the clinical practice with the …
Cell-based assay approaches for glycosaminoglycan synthase high-throughput screening: development and applications
HY Hu, JQ Deng, YJ Wang, Y Li, XL Meng… - ACS Chemical …, 2023 - ACS Publications
Glycosaminoglycan synthases have immense potential in applications involving synthesis of
oligosaccharides, using enzymatic approaches and construction of cell factories that …
oligosaccharides, using enzymatic approaches and construction of cell factories that …
Mechanically stressed cancer microenvironment: Role in pancreatic cancer progression
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies in
the world due to its insensitivity to current therapies and its propensity to metastases from the …
the world due to its insensitivity to current therapies and its propensity to metastases from the …
[HTML][HTML] Structural insights into how proteoglycans determine chemokine-CXCR1/CXCR2 interactions: progress and challenges
K Rajarathnam, UR Desai - Frontiers in immunology, 2020 - frontiersin.org
Proteoglycans (PGs), present in diverse environments, such as the cell membrane surface,
extracellular milieu, and intracellular granules, are fundamental to life. Sulfated …
extracellular milieu, and intracellular granules, are fundamental to life. Sulfated …
Application of biomaterials in periodontal tissue repair and reconstruction in the presence of inflammation under periodontitis through the foreign body response …
C Chu, X Zhao, S Rung, W Xiao, L Liu… - Journal of Biomedical …, 2022 - Wiley Online Library
Periodontitis would cause dental tissue damage locally. Biomaterials substantially affect the
surrounding immune microenvironment through treatment‐oriented local inflammatory …
surrounding immune microenvironment through treatment‐oriented local inflammatory …
Glycosaminoglycans
Glycosaminoglycans (GAGs) are important constituents of human glycome. They are
negatively charged unbranched polysaccharides that are usually covalently attached to …
negatively charged unbranched polysaccharides that are usually covalently attached to …