[HTML][HTML] Advances in the immunomodulatory properties of glycoantigens in cancer

V da Costa, T Freire - Cancers, 2022 - mdpi.com
Simple Summary This work reviews the role of aberrant glycosylation in cancer cells during
tumour growth and spreading, as well as in immune evasion. The interaction of tumour …

Solvent model benchmark for molecular dynamics of glycosaminoglycans

M Marcisz, SA Samsonov - Journal of chemical information and …, 2023 - ACS Publications
In computational studies of glycosaminoglycans (GAGs), a group of anionic, periodic linear
polysaccharides, so far there has been very little discussion about the role of solvent models …

[HTML][HTML] Biomaterial considerations for ovarian cancer models

M Kramer, A Criswell, MK Sewell-Loftin - Frontiers in Materials, 2023 - frontiersin.org
Ovarian cancer is the 5th most common and the deadliest gynecological cancer, with a 5-
year survival rate of less than 50 percent. Most deaths due to ovarian cancer are caused by …

[HTML][HTML] Altered glycosylation in progression and management of bladder cancer

M Wilczak, M Surman, M Przybyło - Molecules, 2023 - mdpi.com
Bladder cancer (BC) is the 10th most common malignancy worldwide, with an estimated
573,000 new cases and 213,000 deaths in 2020. Available therapeutic approaches are still …

[HTML][HTML] Heparan sulfate glycosaminoglycans:(Un) Expected allies in cancer clinical management

I Faria-Ramos, J Poças, C Marques, J Santos-Antunes… - Biomolecules, 2021 - mdpi.com
In an era when cancer glycobiology research is exponentially growing, we are witnessing a
progressive translation of the major scientific findings to the clinical practice with the …

Cell-based assay approaches for glycosaminoglycan synthase high-throughput screening: development and applications

HY Hu, JQ Deng, YJ Wang, Y Li, XL Meng… - ACS Chemical …, 2023 - ACS Publications
Glycosaminoglycan synthases have immense potential in applications involving synthesis of
oligosaccharides, using enzymatic approaches and construction of cell factories that …

Mechanically stressed cancer microenvironment: Role in pancreatic cancer progression

M Hadden, A Mittal, J Samra, H Zreiqat, S Sahni… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies in
the world due to its insensitivity to current therapies and its propensity to metastases from the …

[HTML][HTML] Structural insights into how proteoglycans determine chemokine-CXCR1/CXCR2 interactions: progress and challenges

K Rajarathnam, UR Desai - Frontiers in immunology, 2020 - frontiersin.org
Proteoglycans (PGs), present in diverse environments, such as the cell membrane surface,
extracellular milieu, and intracellular granules, are fundamental to life. Sulfated …

Application of biomaterials in periodontal tissue repair and reconstruction in the presence of inflammation under periodontitis through the foreign body response …

C Chu, X Zhao, S Rung, W Xiao, L Liu… - Journal of Biomedical …, 2022 - Wiley Online Library
Periodontitis would cause dental tissue damage locally. Biomaterials substantially affect the
surrounding immune microenvironment through treatment‐oriented local inflammatory …

Glycosaminoglycans

Y Song, F Zhang, RJ Linhardt - The role of glycosylation in health and …, 2021 - Springer
Glycosaminoglycans (GAGs) are important constituents of human glycome. They are
negatively charged unbranched polysaccharides that are usually covalently attached to …