High-throughput screening of natural product and synthetic molecule libraries for antibacterial drug discovery

NJ Ayon - Metabolites, 2023 - mdpi.com
Due to the continued emergence of resistance and a lack of new and promising antibiotics,
bacterial infection has become a major public threat. High-throughput screening (HTS) …

Kaempferol inhibits the expression of α-hemolysin and protects mice from methicillin-resistant Staphylococcus aureus-induced lethal pneumonia

N Yin, X Yang, L Wang, C Zhang, J Guan, Y Tao… - Microbial …, 2022 - Elsevier
Staphylococcus aureus (S. aureus) is a common pathogenic bacterium that induces a
variety of diseases in humans and animals. The significant pathogenicity of S. aureus is due …

Single crystal X-ray diffraction analysis, spectroscopic measurement, quantum chemical studies, antimicrobial potency and molecular docking of a new [Co (NCS) 4] 2 …

C Gharbi, H Louis, B Essghaier, CB Ubah… - Journal of Molecular …, 2024 - Elsevier
A new cobalt (II) complex was synthesized and characterized by physicochemical
evidences. According to crystallography study, the molecular structure consisting of anionic …

[HTML][HTML] Small-molecule compound SYG-180-2-2 attenuates Staphylococcus aureus virulence by inhibiting hemolysin and staphyloxanthin production

L Rao, Y Xu, L Shen, X Wang, H Zhao… - Frontiers in Cellular …, 2022 - frontiersin.org
Multi-drug resistant Staphylococcus aureus infection is still a serious threat to global health.
Therefore, there is an urgent need to develop new antibacterial agents based on virulence …

ML364 exerts the broad-spectrum antivirulence effect by interfering with the bacterial quorum sensing system

Y Zhang, L Dong, L Sun, X Hu, X Wang, T Nie… - Frontiers in …, 2022 - frontiersin.org
Antivirulence strategy has been developed as a nontraditional therapy which would
engender a lower evolutionary pressure toward the development of antimicrobial resistance …

A natural inhibitor of diapophytoene desaturase attenuates methicillin‐resistant Staphylococcus aureus (MRSA) pathogenicity and overcomes drug‐resistance

B Han, H Wang, X Niu - British Journal of Pharmacology, 2024 - Wiley Online Library
Abstract Background and Purpose At present, the inhibition of staphyloxanthin biosynthesis
has emerged as a prominent strategy in combating methicillin‐resistant Staphylococcus …

Photolysis of methicillin-resistant Staphylococcus aureus using Cu-doped carbon spheres

J Xi, L An, G Wei, Y Huang, D Li, L Fan, L Gao - Biomaterials Science, 2020 - pubs.rsc.org
Developing alternative treatment strategies against methicillin-resistant Staphylococcus
aureus (MRSA) infections is a challenge but could have many potential applications. In this …

Crippling of Klebsiella pneumoniae virulence by metformin, N-acetylcysteine and secnidazole

S M. Shafik, HA Abbas, N Yousef, MM Saleh - BMC microbiology, 2023 - Springer
Introduction The emergence of multidrug-resistant Klebsiella pneumoniae in hospitals
represents a serious threat to public health. Infections caused by Klebsiella pneumoniae are …

Uncovering virulence factors in Cronobacter sakazakii: insights from genetic screening and proteomic profiling

X Chen, J Xue, X Dong, P Lu - Applied and Environmental …, 2023 - Am Soc Microbiol
The increasing problem of antibiotic resistance has driven the search for virulence factors in
pathogenic bacteria, which can serve as targets for the development of new antibiotics …

The determination of the biological function of bacterial pink pigment and Fusarium chlamydosporum on alfalfa (Medicago sativa L.)

R Huang, H Zhang, H Chen, L He, X Liu… - Frontiers in …, 2023 - frontiersin.org
Bacterial pigment is one of the secondary metabolites produced by bacteria and has
functions that are yet to be understood in relation to soil-borne pathogenic fungi and plants …