RNA-binding proteins play a key role in the regulation of all aspects of RNA metabolism,
from the synthesis of RNA to its decay. Protein-RNA interactions have been thought to be …

Abstract N 6-methyladenosine (m6A) modification is an important mechanism in miRNA
processing and maturation, but the role of its aberrant regulation in human diseases …

Ferroptosis is a form of cell death characterized by lipid peroxidation. Previous studies have
reported that knockout of NF-κB activating protein (NKAP), an RNA-binding protein …

Nuclear speckles are small, membrane-less organelles that reside within the nucleus.
Nuclear speckles serve as a regulatory hub coordinating complex RNA metabolism steps …

Well-balanced and timed metabolism is essential for making a high-quality egg. However,
the metabolic framework that supports oocyte development remains poorly understood …

During exon ligation, the Saccharomyces cerevisiae spliceosome recognizes the 3′-splice
site (3′ SS) of precursor messenger RNA (pre-mRNA) through non–Watson-Crick pairing …

The Jumonji domain–containing protein JMJD6 is a 2-oxoglutarate–dependent dioxygenase
associated with a broad range of biological functions. Cellular studies have implicated the …

Persistent R-loop accumulation can cause DNA damage and lead to genome instability,
which contributes to various human diseases. Identification of molecules and signaling …

Gastrointestinal (GI) cancers, including colorectal, gastric, hepatic, esophageal, and
pancreatic tumors, are responsible for large numbers of deaths around the world …

Biomolecular condensates, sometimes also known as membraneless organelles (MLOs),
can form through weak multivalent intermolecular interactions of proteins and nucleic acids …