The MOZ-TIF2 fusion is associated with acute myeloid leukemia (AML) with inv (8)(p11q13).
MOZ is a MYST family histone acetyltransferase (HAT), whereas TIF2 is a nuclear receptor …

Lysine residues are subject to many forms of covalent modification and one such
modification is acetylation of the ε-amino group. Initially identified on histone proteins in the …

During the last three decades it has become apparent that the majority of cases of acute
myeloid leukaemia (AML) are characterized by at least one of a variety of recurrent …

The lysine acetyltransferase KAT6A (MOZ, MYST3) belongs to the MYST family of chromatin
regulators, facilitating histone acetylation. Dysregulation of KAT6A has been implicated in …

The monocytic leukemia zinc finger protein MOZ and its homologue MORF have been
implicated in leukemogenesis. Both MOZ and MORF are histone acetyltransferases with …

Acetylation of lysines on nucleosomal histones has long been perceived as being
responsible for weakening DNA− histone interactions, thereby influencing gene …

The molecular processes governing hematopoiesis involve the interplay between lineage-
specific transcription factors and a series of epigenetic tags, including DNA methylation and …

Genes of the human monocytic leukemia zinc-finger protein MOZ (HUGO symbol, MYST3)
and its paralog MORF (MYST4) are rearranged in chromosome translocations associated …

Starting from a yeast phenotypic screening performed on 21 compounds, we described the
identification of two small molecules (9 and 18) able to significantly reduce the S. cerevisiae …

Simple Summary This review provides an in depth analysis of the role of bromodomain-
containing proteins in cancer development. As readers of acetylated lysine on nucleosomal …