Cancer continues to pose a severe threat to global health, making pursuing effective
treatments more critical than ever. Traditional therapies, although pivotal in managing …

Drug evaluation has always been an important area of research in the pharmaceutical
industry. However, animal welfare protection and other shortcomings of traditional drug …

Clinically, large diameter artery defects (diameter larger than 6 mm) can be substituted by
unbiodegradable polymers, such as polytetrafluoroethylene. There are many problems in …

Soft tissue defects are a common clinical challenge mostly caused by trauma, congenital
anomalies and oncological surgery. Current soft tissue reconstruction options include …

Tumor vasculature abnormality creates a microenvironment that is not suitable for anti-tumor
immune response and thereby induces resistance to immunotherapy. Remodeling of …

An important characteristic of cancer is aberrant metabolism. Drug resistance, cancer stem
cells, metastasis and tumorigenesis are all significantly impacted by abnormal cancer …

In a myriad of developmental and degenerative brain diseases, characteristic pathological
biomarkers are often associated with cerebral blood flow and vasculature. However, the …

Complications with atherosclerosis can often lead to fatal clot formation and blood vessel
occlusion–also known as atherothrombosis. A key component to the development of …

Organ-on-a-chip, which recapitulates the dynamics of in vivo vasculature, has emerged as a
promising platform for studying organ-specific vascular beds. However, its practical …

Engineered human tissues created by three-dimensional cell culture of human cells in a
hydrogel are becoming emerging model systems for cancer drug discovery and …