Expanding antibiotic, vaccine, and diagnostics development and access to tackle antimicrobial resistance
The increasing number of bacterial infections globally that do not respond to any available
antibiotics indicates a need to invest in—and ensure access to—new antibiotics, vaccines …
antibiotics indicates a need to invest in—and ensure access to—new antibiotics, vaccines …
[HTML][HTML] Systematic metareview of prediction studies demonstrates stable trends in bias and low PROBAST inter-rater agreement
Objectives To (1) explore trends of risk of bias (ROB) in prediction research over time
following key methodological publications, using the Prediction model Risk Of Bias …
following key methodological publications, using the Prediction model Risk Of Bias …
[HTML][HTML] A prognostic model for critically ill children in locations with emerging critical care capacity
A Chandna, S Keang, M Vorlark… - Pediatric Critical Care …, 2024 - journals.lww.com
OBJECTIVES: To develop a clinical prediction model to risk stratify children admitted to
PICUs in locations with limited resources, and compare performance of the model to nine …
PICUs in locations with limited resources, and compare performance of the model to nine …
Digitalizing clinical guidelines: experiences in the development of clinical decision support algorithms for management of childhood illness in resource-constrained …
F Beynon, F Guérin, R Lampariello… - … Health: Science and …, 2023 - ghspjournal.org
Clinical decision support systems (CDSSs) can strengthen the quality of integrated
management of childhood illness (IMCI) in resource-constrained settings. Several IMCI …
management of childhood illness (IMCI) in resource-constrained settings. Several IMCI …
[HTML][HTML] ePOCT+ and the medAL-suite: Development of an electronic clinical decision support algorithm and digital platform for pediatric outpatients in low- and …
Electronic clinical decision support algorithms (CDSAs) have been developed to address
high childhood mortality and inappropriate antibiotic prescription by helping clinicians …
high childhood mortality and inappropriate antibiotic prescription by helping clinicians …
Anticipating the future: prognostic tools as a complementary strategy to improve care for patients with febrile illnesses in resource-limited settings
In low-income and middle-income countries, most patients with febrile illnesses present to
peripheral levels of the health system where diagnostic capacity is very limited. In these …
peripheral levels of the health system where diagnostic capacity is very limited. In these …
The impact of pulse oximetry on diagnosis, management and outcomes of acute febrile illness in low-income and middle-income countries: a systematic review
Background Acute fever is a common presenting symptom in low/middle-income countries
(LMICs) and is strongly associated with sepsis. Hypoxaemia predicts disease severity in …
(LMICs) and is strongly associated with sepsis. Hypoxaemia predicts disease severity in …
[HTML][HTML] External validation of clinical severity scores to guide referral of paediatric acute respiratory infections in resource-limited primary care settings
A Chandna, L Mwandigha, C Koshiaris… - Scientific Reports, 2023 - nature.com
Accurate and reliable guidelines for referral of children from resource-limited primary care
settings are lacking. We identified three practicable paediatric severity scores (the Liverpool …
settings are lacking. We identified three practicable paediatric severity scores (the Liverpool …
External validation and updating of clinical severity scores to guide referral of young children with acute respiratory infections in resource-limited primary care settings
A Chandna, L Mwandigha, C Koshiaris… - medRxiv, 2022 - medrxiv.org
Background Accurate and reliable guidelines for referral of children from resource-limited
primary care settings are lacking. We identified three practicable paediatric severity scores …
primary care settings are lacking. We identified three practicable paediatric severity scores …
Febrile phase soluble urokinase plasminogen activator receptor and olfactomedin 4 as prognostic biomarkers for severe dengue in adults
Background Dengue cases continue to rise and can overwhelm healthcare systems during
outbreaks. In dengue, neutrophil mediators, soluble urokinase plasminogen activator …
outbreaks. In dengue, neutrophil mediators, soluble urokinase plasminogen activator …