Multilocus sequence typing (MLST) was proposed in 1998 as a portable sequence-based
method for identifying clonal relationships among bacteria. Today, in the whole-genome era …

Behaviours of complex biomolecular systems are often irreducible to the elementary
properties of their individual components. Explanatory and predictive mathematical models …

Chemical genomics aims to comprehensively define, and ultimately predict, the effects of
small molecule compounds on biological systems. Chemical activity profiling approaches …

Research in several fields now requires the analysis of datasets in which multiple high-
dimensional types of data are available for a common set of objects. In particular, The …

Mendelian randomization (MR) is an approach that uses genetic variants associated with a
modifiable exposure or biological intermediate to estimate the causal relationship between …

The iPlant Collaborative (iPlant) is a United States National Science Foundation (NSF)
funded project that aims to create an innovative, comprehensive, and foundational …

Web services are the de facto standard in biomedical data integration. However, there are
data integration scenarios that cannot be fully covered by Web services. A number of Web …

Open PHACTS is a public–private partnership between academia, publishers, small and
medium sized enterprises and pharmaceutical companies. The goal of the project is to …

Abstract The Human Genome Project has transformed biology through its integrated big
science approach to deciphering a reference human genome sequence along with the …

Background Recently, rapid improvements in technology and decrease in sequencing costs
have made RNA-Seq a widely used technique to quantify gene expression levels. Various …