[HTML][HTML] Extracellular vesicle-microRNAs as diagnostic biomarkers in preterm neonates

EA Schiller, K Cohen, X Lin, R El-Khawam… - International Journal of …, 2023 - mdpi.com
Neonates born prematurely (< 37 weeks of gestation) are at a significantly increased risk of
developing inflammatory conditions associated with high mortality rates, including …

MicroRNA therapeutic targets in neonatal hypoxic–ischemic brain injury: a narrative review

ES Peeples - Pediatric research, 2023 - nature.com
Neonatal hypoxic–ischemic brain injury (HIBI) is a devastating injury resulting from impaired
blood flow and oxygen delivery to the brain at or around the time of birth. Despite the use of …

[HTML][HTML] Hypoglycemia, Vascular Disease and Cognitive Dysfunction in Diabetes: Insights from Text Mining-Based Reconstruction and Bioinformatics Analysis of the …

OV Saik, VV Klimontov - International Journal of Molecular Sciences, 2021 - mdpi.com
Hypoglycemia has been recognized as a risk factor for diabetic vascular complications and
cognitive decline, but the molecular mechanisms of the effect of hypoglycemia on target …

[HTML][HTML] DNA methylation-mediated repression of microRNA-410 promotes the growth of human glioma cells and triggers cell apoptosis through its interaction with …

Z Wenfu, L Bin, R Binchan, L Jingling, W Zhenchang… - Scientific Reports, 2024 - nature.com
This study's purpose was to confirm the observed underexpression of miRNA-410 in glioma
tissues and several glioma cells by Quantitative RT-PCR. Our findings suggest that …

[HTML][HTML] Neuronal responses to ischemia: scoping review of insights from human-derived in vitro models

EJHF Voogd, M Frega, J Hofmeijer - Cellular and molecular neurobiology, 2023 - Springer
Translation of neuroprotective treatment effects from experimental animal models to patients
with cerebral ischemia has been challenging. Since pathophysiological processes may vary …

[HTML][HTML] Hypoxic/ischemic inflammation, microRNAs and δ-opioid receptors: hypoxia/ischemia-sensitive versus-insensitive organs

Y Chen, Y He, S Zhao, X He, D Xue… - Frontiers in Aging …, 2022 - frontiersin.org
Hypoxia and ischemia cause inflammatory injury and critically participate in the
pathogenesis of various diseases in various organs. However, the protective strategies …

[HTML][HTML] The protective effect of MiR-27a on the neonatal hypoxic-ischemic encephalopathy by targeting FOXO1 in rats

Q Cai, X Zhang, L Shen, H Song, T Wang - Translational Pediatrics, 2022 - ncbi.nlm.nih.gov
Background Neonatal hypoxic-ischemic encephalopathy (HIE), a kind of hypoxic-ischemic
brain damage caused by perinatal asphyxia, is the most crucial cause of neonatal death and …

[HTML][HTML] LncRNA-mir3471-limd1 regulatory network plays critical roles in HIBD

L Sun, J Wan, B Sun, Q Tian, M Li, LX Xu… - Experimental Brain …, 2024 - Springer
The purpose of this study was to identify the target genes of tcon_00044595, elucidate its
activation site, and provide novel insights into the pathogenesis and treatment of neonatal …

[HTML][HTML] Circulating MicroRNAs as a biomarker signature of perinatal asphyxia

YH Lai, YF Tu, CH Chen, JH Chang, CH Hsu… - Pediatrics & …, 2024 - Elsevier
Aim This study aimed to explore whether microRNAs (miRNAs) could serve as biomarkers of
perinatal asphyxia and whether they were correlated with severity of brain magnetic …

[HTML][HTML] Early brain microRNA/mRNA expression is region-specific after neonatal hypoxic-ischemic injury in a mouse model

ES Peeples, N Sahar, W Snyder, K Mirnics - Frontiers in Genetics, 2022 - frontiersin.org
Background: MicroRNAs (miRNAs) may be promising therapeutic targets for neonatal
hypoxic-ischemic brain injury (HIBI) but targeting miRNA-based therapy will require more …