Plasma Pyruvate Kinase M2 as a marker of vascular inflammation in giant cell arteritis
Objectives GCA is a large vessel vasculitis in which metabolically active immune cells play
an important role. GCA diagnosis is based on CRP/ESR and temporal artery biopsies …
an important role. GCA diagnosis is based on CRP/ESR and temporal artery biopsies …
Thermal and wine processing enhanced Clematidis Radix et Rhizoma ameliorate collagen Ⅱ induced rheumatoid arthritis in rats
SQ Jiang, T Pan, JL Yu, Y Zhang, T Wang, P Li… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Clematidis Radix et Rhizoma, a kind of traditional
Chinese medicine, is derived from Clematis chinensis Osbeck, Clematis hexapetala Pall …
Chinese medicine, is derived from Clematis chinensis Osbeck, Clematis hexapetala Pall …
A perspective on medicinal chemistry approaches for targeting pyruvate kinase M2
The allosteric regulation of pyruvate kinase M2 (PKM2) affects the switching of the PKM2
protein between the high-activity and low-activity states that allow ATP and lactate …
protein between the high-activity and low-activity states that allow ATP and lactate …
Interactions between NLRP3 inflammasome and glycolysis in macrophages: New insights into chronic inflammation pathogenesis
Q Yu, M Guo, W Zeng, M Zeng, X Zhang… - Immunity …, 2022 - Wiley Online Library
NLRP3 inflammasome activation in macrophages fuels sterile inflammation, which has been
tied with metabolic reprogramming characterized by high glycolysis and low oxidative …
tied with metabolic reprogramming characterized by high glycolysis and low oxidative …
Glutathione peroxidase 3 is a novel clinical diagnostic biomarker and potential therapeutic target for neutrophils in rheumatoid arthritis
T Chen, Z Zhou, M Peng, H Hu, R Sun, J Xu… - Arthritis Research & …, 2023 - Springer
Background Neutrophils have a critical role in the pathogenesis of rheumatoid arthritis (RA)
with immune system dysfunction. However, the molecular mechanisms of this process …
with immune system dysfunction. However, the molecular mechanisms of this process …
Glucose metabolic reprogramming in autoimmune diseases
H Jeong, B Lee, SJ Han, DH Sohn - Animal Cells and Systems, 2023 - Taylor & Francis
Autoimmune diseases are conditions in which the immune system mistakenly targets and
damages healthy tissue in the body. In recent decades, the incidence of autoimmune …
damages healthy tissue in the body. In recent decades, the incidence of autoimmune …
The SYSCID map: a graphical and computational resource of molecular mechanisms across rheumatoid arthritis, systemic lupus erythematosus and inflammatory …
ML Acencio, M Ostaszewski, A Mazein… - Frontiers in …, 2023 - frontiersin.org
Chronic inflammatory diseases (CIDs), including inflammatory bowel disease (IBD),
rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are thought to emerge …
rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are thought to emerge …
Triptolide inhibits Th17 differentiation via controlling PKM2-mediated glycolysis in rheumatoid arthritis
MY Shen, X Wang, YX Di, MF Zhang… - …, 2022 - Taylor & Francis
Context Rheumatoid arthritis (RA) is an autoimmune disease with the aberrant differentiation
of T helper 17 (Th17) cells. Pyruvate kinase M2 (PKM2), a key enzyme of glycolysis, was …
of T helper 17 (Th17) cells. Pyruvate kinase M2 (PKM2), a key enzyme of glycolysis, was …
[HTML][HTML] NCF4 regulates antigen presentation of cysteine peptides by intracellular oxidative response and restricts activation of autoreactive and arthritogenic T cells
J Xu, C He, Y Cai, X Wang, J Yan, J Zhang, F Zhang… - Redox Biology, 2024 - Elsevier
Autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematous,
are regulated by polymorphisms in genes contributing to the NOX2 complex. Mutations in …
are regulated by polymorphisms in genes contributing to the NOX2 complex. Mutations in …
[HTML][HTML] Assessment of disease activity in patients with rheumatoid arthritis using plasma tumour M2-pyruvate kinase test
SS Ahn, HM Kim, Y Park - Frontiers in Immunology, 2022 - frontiersin.org
Background Pyruvate kinase M2 (PKM2) is an enzyme that regulates the final process of
glycolysis and exists in tetrameric and dimeric forms. The dimeric form of PKM2, also known …
glycolysis and exists in tetrameric and dimeric forms. The dimeric form of PKM2, also known …