In brief The syndrome of preterm labor comprises multiple established and novel etiologies.
This review summarizes the distinct immune mechanisms implicated in preterm labor and …

Activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome
drives release of the proinflammatory cytokines interleukin (IL)-1 β and IL-18 and induces …

Macrophages are commonly thought to contribute to the pathophysiology of preterm labor by
amplifying inflammation—but a protective role has not previously been considered to our …

Regulatory T cells (Tregs) have been exhaustively investigated during early pregnancy;
however, their role later in gestation is poorly understood. Herein, we report that functional …

Inflammasomes are cytoplasmic multiprotein complexes that coordinate inflammatory
responses, including those that take place during pregnancy. Inflammasomes and their …

Preterm labor commonly precedes preterm birth, the leading cause of perinatal morbidity
and mortality worldwide. Most research has focused on establishing a causal link between …

Intra-amniotic inflammation is strongly associated with spontaneous preterm labor and birth,
the leading cause of perinatal mortality and morbidity worldwide. Previous studies have …

Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. One of
every 4 preterm neonates is born to a mother with intra-amniotic inflammation driven by …

Programmed cell deaths are pathways involving cells playing an active role in their own
destruction. Depending on the signaling system of the process, programmed cell death can …

Objectives Clinical chorioamnionitis at term is considered the most common infection-related
diagnosis in labor and delivery units worldwide. The syndrome affects 5–12% of all term …