[HTML][HTML] Polymer-and lipid-based nanocarriers for ocular drug delivery: current status and future perspectives

H Han, S Li, M Xu, Y Zhong, W Fan, J Xu, T Zhou… - Advanced Drug Delivery …, 2023 - Elsevier
Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of
over 43 million blindness. However, efficient drug delivery to treat ocular diseases …

[HTML][HTML] Immune responses to injury and their links to eye disease

MANN Stepp, ASUE Menko - Translational Research, 2021 - Elsevier
The eye is regarded as an immune privileged site. Since the presence of a vasculature
would impair vision, the vasculature of the eye is located outside of the central light path. As …

The lens epithelium as a major determinant in the development, maintenance, and regeneration of the crystalline lens

Z Liu, S Huang, Y Zheng, T Zhou, L Hu, L Xiong… - Progress in retinal and …, 2023 - Elsevier
The crystalline lens is a transparent and refractive biconvex structure formed by lens
epithelial cells (LECs) and lens fibers. Lens opacity, also known as cataracts, is the leading …

[HTML][HTML] The role of IL-6 in fibrotic diseases: molecular and cellular mechanisms

Y Li, J Zhao, Y Yin, K Li, C Zhang… - International journal of …, 2022 - ncbi.nlm.nih.gov
Fibrosis is a detrimental outcome of most chronic inflammatory disorders and is defined by
the buildup of excess extracellular matrix (ECM) components, which eventually leads to …

Centrifugally concentric ring-patterned drug-loaded polymeric coating as an intraocular lens surface modification for efficient prevention of posterior capsular …

D Lu, Y Han, D Liu, S Chen, J Qie, J Qu, Q Lin - Acta Biomaterialia, 2022 - Elsevier
Posterior capsular opacification (PCO) is the main postoperative complication after
intraocular lens (IOL) implantation in cataract surgery, because of the proliferation of the …

Biliverdin/Bilirubin Redox Pair Protects Lens Epithelial Cells against Oxidative Stress in Age‐Related Cataract by Regulating NF‐κB/iNOS and Nrf2/HO‐1 Pathways

Y Huang, J Li, W Li, N Ai, H Jin - Oxidative medicine and …, 2022 - Wiley Online Library
Age‐related cataract (ARC) is the leading cause of vision impairment globally. It has been
widely accepted that excessive reactive oxygen species (ROS) accumulation in lens …

[HTML][HTML] Research progress concerning a novel intraocular lens for the prevention of posterior capsular opacification

Y Zhang, C Zhang, S Chen, J Hu, L Shen, Y Yu - Pharmaceutics, 2022 - mdpi.com
Posterior capsular opacification (PCO) is the most common complication resulting from
cataract surgery and limits the long-term postoperative visual outcome. Using Nd: YAG laser …

[HTML][HTML] Aged Lens Epithelial Cells Suppress Proliferation and Epithelial–Mesenchymal Transition-Relevance for Posterior Capsule Opacification

Z Wei, P Gordon, C Hao, J Huangfu, E Fan, X Zhang… - Cells, 2022 - mdpi.com
Posterior capsule opacification (PCO) is a frequent complication after cataract surgery, and
advanced PCO requires YAG laser (Nd: YAG) capsulotomy, which often gives rise to more …

NIR-triggered drug delivery system for chemo-photothermal therapy of posterior capsule opacification

M Ying-Yan, L Meng, W Jin-Da, W Kai-Jie… - Journal of Controlled …, 2021 - Elsevier
Posterior capsule opacification (PCO) is the most common complication after cataract
surgery and is likely to cause the second loss of vision. Pharmacological PCO prophylaxis …

[HTML][HTML] Lens epithelial explants treated with vitreous humor undergo alterations in chromatin landscape with concurrent activation of genes associated with fiber cell …

A Upreti, SL Padula, JA Tangeman, BD Wagner… - Cells, 2023 - mdpi.com
Lens epithelial explants are comprised of lens epithelial cells cultured in vitro on their native
basement membrane, the lens capsule. Biologists have used lens epithelial explants to …