pH plays a role in the mode of action of trimethoprim on Escherichia coli

H AlRabiah, JW Allwood, E Correa, Y Xu… - PLoS One, 2018 - journals.plos.org
Metabolomics-based approaches were applied to understand interactions of trimethoprim
with Escherichia coli K-12 at sub-minimum inhibitory concentrations (MIC≈ 0.2, 0.03 and …

Metabolomics for the design of new metabolic engineering strategies for improving aerobic succinic acid production in Escherichia coli

A Valle, Z Soto, H Muhamadali, KA Hollywood, Y Xu… - Metabolomics, 2022 - Springer
Introduction Glycerol is a byproduct from the biodiesel industry that can be biotransformed
by Escherichia coli to high added-value products such as succinate under aerobic …

Postgenomics diagnostics: Metabolomics approaches to human blood profiling

O Trifonova, P Lokhov, A Archakov - Omics: a journal of integrative …, 2013 - liebertpub.com
We live in exciting times with the prospects of postgenomics diagnostics. Metabolomics is a
novel “omics” data-intensive science that is accelerating the development of postgenomics …

Metabolic profiling reveals potential metabolic markers associated with Hypoxia Inducible Factor-mediated signalling in hypoxic cancer cells

EG Armitage, HL Kotze, JW Allwood, WB Dunn… - Scientific Reports, 2015 - nature.com
Hypoxia inducible factors (HIFs) plays an important role in oxygen compromised
environments and therefore in tumour survival. In this research, metabolomics has been …

High-throughput microbore UPLC–MS metabolic phenotyping of urine for large-scale epidemiology studies

N Gray, MR Lewis, RS Plumb, ID Wilson… - Journal of proteome …, 2015 - ACS Publications
A new generation of metabolic phenotyping centers are being created to meet the
increasing demands of personalized healthcare, and this has resulted in a major …

Evaluation of dried blood spots as sample matrix for gas chromatography/mass spectrometry based metabolomic profiling

ST Kong, HS Lin, J Ching, PC Ho - Analytical chemistry, 2011 - ACS Publications
We propose using dried blood spots (DBS) as sample matrix for gas chromatography/mass
spectrometry (GC/MS) based metabolomic profiling for the benefits of higher sample …

Metabolic impairments, metal traffic, and dyshomeostasis caused by the antagonistic interaction of cadmium and selenium using organic and inorganic mass …

G Rodríguez-Moro, FN Roldán, R Baya-Arenas… - … science and pollution …, 2020 - Springer
Cadmium (Cd) has become one of the most important environmental pollutants in the world,
derived from natural and industrial sources, which is known to be accumulated in the human …

Comparative effects of mercury chloride and methylmercury exposure on early neurodevelopment in zebrafish larvae

J Zhu, C Wang, X Gao, J Zhu, L Wang, S Cao, Q Wu… - RSC …, 2019 - pubs.rsc.org
Mercury (Hg) is a ubiquitous environmental toxicant with important public health
implications. Hg causes neurotoxicity through astrocytes, Ca2+, neurotransmitters …

Ultra-Performance liquid chromatography–high-resolution mass spectrometry and direct infusion–high-resolution mass spectrometry for combined exploratory and …

E Chekmeneva, G dos Santos Correia… - Journal of proteome …, 2018 - ACS Publications
The application of metabolic phenotyping to epidemiological studies involving thousands of
biofluid samples presents a challenge for the selection of analytical platforms that meet the …

Accelerated solvent extraction for GC-based tobacco fingerprinting and its comparison with simultaneous distillation and extraction

Y Li, T Pang, Z Guo, Y Li, X Wang, J Deng, K Zhong… - Talanta, 2010 - Elsevier
An accelerated solvent extraction (ASE) procedure has been developed as a pretreatment
method for chemical fingerprinting of volatile and semi-volatile components in cut tobacco …