[HTML][HTML] The impact of histone modifications in endometriosis highlights new therapeutic opportunities

I Psilopatis, K Vrettou, FN Fleckenstein, S Theocharis - Cells, 2023 - mdpi.com
Endometriosis is a chronic disorder of the female reproductive system which afflicts a great
number of women worldwide. Histone deacetylases (HDACs) prevent the relaxation of …

[HTML][HTML] The Role of Bitter Melon in Breast and Gynecological Cancer Prevention and Therapy

I Psilopatis, K Vrettou, C Giaginis… - International Journal of …, 2023 - mdpi.com
Phytotherapy has long represented a widely accepted treatment alternative to conventional
therapy. Bitter melon is a vine with potent antitumor effects against numerous cancer entities …

The Evolving Landscape of Cervical Cancer: Breakthroughs in Screening and Therapy Through Integrating Biotechnology and Artificial Intelligence

R Aswathy, S Sumathi - Molecular Biotechnology, 2024 - Springer
Cervical cancer (CC) continues to be a major worldwide health concern, profoundly
impacting the lives of countless females worldwide. In low-and middle-income countries …

Investigating Potential Cancer Therapeutics: Insight into Histone Deacetylases (HDACs) Inhibitions

B Ahmad, A Saeed, A Al-Amery, I Celik, I Ahmed… - Pharmaceuticals, 2024 - mdpi.com
Histone deacetylases (HDACs) are enzymes that remove acetyl groups from ɛ-amino of
histone, and their involvement in the development and progression of cancer disorders …

[HTML][HTML] The Clinical Impact of Death Domain-Associated Protein and Holliday Junction Recognition Protein Expression in Cancer: Unmasking the Driving Forces of …

A Pergaris, I Genaris, IE Stergiou, J Klijanienko… - Cancers, 2023 - mdpi.com
Simple Summary DAXX and HJURP are two proteins implicated in many physiologic
processes and are considered important players contributing to the pathogenesis of a …

[HTML][HTML] The Role of Receptor–Ligand Interaction in Somatostatin Signaling Pathways: Implications for Neuroendocrine Tumors

A Milewska-Kranc, JB Ćwikła, A Kolasinska-Ćwikła - Cancers, 2023 - mdpi.com
Simple Summary The tissue expression of somatostatin receptor (SSTR) subtypes in
neuroendocrine tumors (NETs) holds paramount significance with far-reaching diagnostic …

[HTML][HTML] Regulatory Roles of Histone Deacetylation in Metabolic Stress-Induced Expression of Caspase Recruitment Domain-Containing Protein 9 (CARD9) in …

M Hali, N Pinto, N Gleason, A Kowluru - International Journal of …, 2023 - mdpi.com
CARD9, a scaffolding protein, has been implicated in the pathogenesis of metabolic
diseases, including obesity and diabetes. We recently reported novel roles for CARD9 in …

[HTML][HTML] Evaluation of the Histone Deacetylase 2 (HDAC-2) Expression in Human Breast Cancer

C Damaskos, I Psilopatis, A Garmpi, D Dimitroulis… - Cancers, 2024 - mdpi.com
Simple Summary Histone deacetylase inhibitors (HDACIs) represent a relatively new drug
class with potent regulatory effects on the epigenetics in cancer, ranging from apoptosis …

Deacetylation of Histones and Non-histone Proteins in Inflammatory Diseases and Cancer Therapeutic Potential of Histone Deacetylase Inhibitors

E Man, S Evran - Current Genomics, 2023 - ingentaconnect.com
Epigenetic changes play an important role in the pathophysiology of autoimmune diseases
such as allergic asthma, multiple sclerosis, lung diseases, diabetes, cystic fibrosis …

Long non-coding RNA SOX21-AS1: A potential tumor oncogene in human cancers

Z Lu, J Xu, B Cao, C Jin - Pathology-Research and Practice, 2023 - Elsevier
Emerging data have proposed that the aberrant level of long noncoding RNAs (lncRNA) is
related to the onset and progression of cancer. Among them, lncRNA SOX21-AS1 was …