Opiate dependence and withdrawal involve neuroadaptive responses in the central nervous
system. A host of studies have previously implicated the A6 noradrenergic neurons of the …

Most neurotransmitter and hormone receptors can be grouped into a series of receptor
“superfamilies.” Receptors in each of these groups share a number of common properties …

Since opioids can influence the release of acetylcholine, substance P and a number of other
neurotransmitter that have been implicated in the pathogenesis of Alzheimer's disease (AD) …

Introduction: Opioid receptor antagonists are well known for their ability to attenuate or
reverse the effects of opioid agonists. This property has made them useful in mitigating …

Synaptic transmission plays a central role in the nervous system as the mechanism that
allows for chemical and electrical communication between cells and thus connects discrete …

There appear to be two anatomically distinct β‐endorphin (βE) pathways in the brain, the
major one originating in the arcuate nucleus of the hypothalamus and a smaller one in the …

Mammalian Neuroendocrinology presents a concise examination of how the nervous and
endocrine systems interact to regulate physiological processes. Selected experimental …

Abstract Opioid growth factor (OGF),[Met 5] enkephalin, serves as an inhibitory influence on
the developing nervous system and is especially targeted to cell proliferative events. OGF …

The mechanisms involved in the development of morphine tolerance and dependence are
still unknown. Recently much attention has been directed toward the changes in post …

We have used a sensitive solution hybridization assay with a riboprobe transcribed from the
coding sequence of the δ opioid receptor (DOR) to quantitate the changes in DOR mRNA …