We investigated the effect of long-term administration of opioid antagonists on the regulation
of prodynorphin gene expression in rat brain. Intracerebroventricular (icv) injections for …

Neostriatal GABAergic neurons projecting to the globus pallidus synthesize the opioid
peptide enkephalin, while those innervating the substantia nigra pars reticulata and the …

Exposure of C 6 glial cell cultures to desipramine induced the appearance of opioid
receptors and up-regulated σ receptors. Opioid binding was demonstrated with 3 H …

Opioid antagonists such as naltrexone, naloxone, and ICI 174864 induce a transient
downregulation of δ opioid receptors prior to upregulation in NG108-15 cells. Here we show …

The antinociceptive potency of the delta opioid receptor (DOR) agonist [D-Ala2] Deltorphin II
and the levels of DOR mRNA were measured in mice chronically treated with naltrexone …

Cholecystokinin, substance P and methionine enkephalin all regulate the display of
reproductive behaviour. Their expression is exquisitely regulated by estrogen in the limbic …

An in situ hybridization histochemical procedure was developed to monitor the cellular
distributions of the three major alternatively spliced α, β and γ species of mRNA encoding …

The effect of dopamine (DA) on the binding of [3H] phorbol 12, 13‐dibutyrate ([3H] PdBu) in
cultured rat striatal cells was examined. DA maximally increased specific [3H] PdBu binding …

G αs mRNA levels were measured in brain regions of newborn pups following prenatal
morphine treatment. A significant decrease (24%) in G αs mRNA levels was observed in the …

The molecular mechanisms underlying behavioral and physiological events associated with
the intake of addictive drugs such as cocaine, amphetamine, and opiates are poorly …