The η-class carbonic anhydrases as drug targets for antimalarial agents
CT Supuran, C Capasso - Expert opinion on therapeutic targets, 2015 - Taylor & Francis
Introduction: The η-class of carbonic anhydrases (CAs, EC 4.2. 1.1) was recently discovered
as the sixth genetic family of this metalloenzyme superfamily, and seems to be present only …
as the sixth genetic family of this metalloenzyme superfamily, and seems to be present only …
The impact of maternal malaria on newborns
TK Hartman, SJ Rogerson… - Annals of tropical …, 2010 - Taylor & Francis
Background: Each year, malaria threatens 125 million pregnancies, and gestational malaria
is responsible for up to 200,000 infant deaths in sub-Saharan Africa. With advancing …
is responsible for up to 200,000 infant deaths in sub-Saharan Africa. With advancing …
[HTML][HTML] Protective efficacy and safety of three antimalarial regimens for the prevention of malaria in young Ugandan children: a randomized controlled trial
V Bigira, J Kapisi, TD Clark, S Kinara, F Mwangwa… - PLoS …, 2014 - journals.plos.org
Background Chemoprevention offers a promising strategy for prevention of malaria in
African children. However, the optimal chemoprevention drug and dosing strategy is unclear …
African children. However, the optimal chemoprevention drug and dosing strategy is unclear …
[HTML][HTML] High prevalence of Pfdhfr–Pfdhps quadruple mutations associated with sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates from …
T Jiang, J Chen, H Fu, K Wu, Y Yao, JUM Eyi… - Malaria journal, 2019 - Springer
Background Sulfadoxine–pyrimethamine (SP) is recommended for intermittent preventive
treatment of malaria in Africa. However, increasing SP resistance (SPR) affects the …
treatment of malaria in Africa. However, increasing SP resistance (SPR) affects the …
[HTML][HTML] Forest malaria and prospects for anti-malarial chemoprophylaxis among forest goers: findings from a qualitative study in Thailand
M Jongdeepaisal, P Khonputsa, O Prasert, S Maneenet… - Malaria journal, 2022 - Springer
Abstract Background Across the Greater Mekong Subregion, malaria remains a dangerous
infectious disease, particularly for people who visit forested areas where residual …
infectious disease, particularly for people who visit forested areas where residual …
Drug repositioning in the treatment of malaria and TB
The emergence and spread of drug resistance in the malaria parasite Plasmodium
falciparum as well as multi-and extremely drug-resistant forms of Mycobacterium …
falciparum as well as multi-and extremely drug-resistant forms of Mycobacterium …
Folate metabolism in human malaria parasites—75 years on
IB Müller, JE Hyde - Molecular and biochemical parasitology, 2013 - Elsevier
Malaria still poses one of the most serious threats to human health worldwide and the
prevailing lack of effective, clinically licensed, vaccines means that prophylaxis and …
prevailing lack of effective, clinically licensed, vaccines means that prophylaxis and …
[HTML][HTML] A Positive Correlation between Atypical Memory B Cells and Plasmodium falciparum Transmission Intensity in Cross-Sectional Studies in Peru and Mali
GE Weiss, EH Clark, S Li, B Traore, K Kayentao… - PloS one, 2011 - journals.plos.org
Background Antibodies that protect against Plasmodium falciparum (Pf) malaria are only
acquired after years of repeated infections. The B cell biology that underlies this observation …
acquired after years of repeated infections. The B cell biology that underlies this observation …
[HTML][HTML] The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y …
Abstract Background The majority of Plasmodium falciparum malaria cases in Africa are
treated with the artemisinin combination therapies artemether-lumefantrine (AL) and …
treated with the artemisinin combination therapies artemether-lumefantrine (AL) and …
Prevalence of Plasmodium falciparum parasites resistant to sulfadoxine/pyrimethamine in the Democratic Republic of the Congo: emergence of highly resistant pfdhfr …
P Nkoli Mandoko, F Rouvier… - Journal of …, 2018 - academic.oup.com
Abstract Background In 2005, the Democratic Republic of the Congo (DRC) switched to
artesunate/amodiaquine as the first-line antimalarial in response to increasing sulfadoxine …
artesunate/amodiaquine as the first-line antimalarial in response to increasing sulfadoxine …