Thyroid cancer is a common endocrine malignancy. There has been exciting progress in
understanding its molecular pathogenesis in recent years, as best exemplified by the …

Thyroid cancer is one of the few malignancies that are increasing in incidence. Recent
advances have improved our understanding of its pathogenesis; these include the …

Abstract The Na+/I− symporter (NIS) is an integral plasma membrane glycoprotein that
mediates active I− transport into the thyroid follicular cells, the first step in thyroid hormone …

Thyroid gland organogenesis results in an organ the shape, size, and position of which are
largely conserved among adult individuals of the same species, thus suggesting that genetic …

The genomic simplicity of differentiated cancers derived from thyroid follicular cells offers
unique insights into how oncogenic drivers impact tumour phenotype. Essentially, the main …

The BRAFT1799A mutation is the most common genetic alteration in papillary thyroid
carcinomas (PTC). It is also found in a subset of papillary microcarcinomas, consistent with a …

Context: TSH is the main factor involved in the control of proliferation of thyrocytes. Recently,
a strong relationship between serum TSH and risk of thyroid malignancy has been reported …

Abstract The RAS-RAF-MEK-ERK-MAP kinase pathway mediates the cellular response to
extracellular signals that regulate cell proliferation, differentiation, and apoptosis. Mutation of …

Abstract Objective Metabolic syndrome (MetS) is a cluster of metabolic abnormalities with
insulin resistance (IR) as a major component. It has been recently questioned whether MetS …

Mutations of BRAF are found in∼ 45% of papillary thyroid cancers and are enriched in
tumors with more aggressive properties. We developed mice with a thyroid-specific knock-in …