Exposure to antioxidants and xenobiotics triggers the expression of a myriad of genes
encoding antioxidant proteins, detoxifying enzymes, and xenobiotic transporters to offer …

This review is the introduction to a special issue concerning, glutathione (GSH), the most
abundant low molecular weight thiol compound synthesized in cells. GSH plays critical roles …

The glutathione S-transferases (GST) represent a major group of detoxification enzymes. All
eukaryotic species possess multiple cytosolic and membrane-bound GST isoenzymes, each …

Reactive Oxygen Species (ROS) are produced during normal cellular function. ROS include
hydroxyl radicals, superoxide anion, hydrogen peroxide and nitric oxide. They are very …

Twenty-four base pairs of the human antioxidant response element (hARE) are required for
high basal transcription of the NAD (P) H: quinone oxidoreductase1 (NQO1) gene and its …

The polyamines are small organic cations that are absolutely required for eukaryotic cell
growth. Although their growth requirements are well established, the molecular functions of …

▪ Abstract Reactive oxygen intermediates are produced in all aerobic organisms during
respiration and exist in the cell in a balance with biochemical antioxidants. Excess reactive …

The metallothioneins (MT) are small, cysteine-rich heavy metal-binding proteins which
participate in an array of protective stress responses. Although a single essential function of …

Several epidemiologic studies suggest that consumption of cruciferous vegetables may be
particularly effective (compared with total fruit and vegetable consumption) in reducing …

NAD (P) H: quinone oxidoreductase 1 (NQO1) is an obligate two-electron reductase that is
involved in chemoprotection and can also bioactivate certain antitumor quinones. This …