IL-6 gene expression is controlled by a promoter region containing multiple regulatory
elements such as NF-κB, NF-IL6, CRE, GRE, and TRE. In this study, we demonstrated that …

Many dietary isothiocyanates (ITCs) have shown cancer chemoprotective activity in animal
models. Isothiocyanates rapidly accumulate in cells of various types as glutathione …

The NAD (P) H: quinone oxidoreductase 1 (NQO1) is a phase II enzyme that reduces and
detoxifies quinones and their derivatives. Although overexpressed in tumor cells, the NQO1 …

Redox regulation of DNA-binding proteins through the reversible oxidation of key cysteine
sulfhydryl groups has been demonstrated to occur in vitro for a range of transcription factors …

Nuclear factor kappa B (NF‐κB) is a protein transcription factor that is required for maximal
transcription of a wide array of pro‐inflammatory mediators that are involved in the …

Metallothioneins (MTs) are a family of small proteins having a molecular weight from 6 to 10
kDa. They are found throughout the animal kingdom, in plants, and in certain eukaryotic and …

Green tea polyphenols, major constituents of green tea, are potent chemopreventive agents
in a number of experimental models of cancer in animals. The mechanisms of cancer …

NQO1 can be induced by multiple forms of stress including oxidative stress. NQO1 is a
pleiotropic enzyme and consideration of some of the known endogenous substrates and …

We have cloned the human γ-glutamylcysteine synthetase heavy subunit gene (GCSh) from
a P1 library and isolated a 5.5 kb fragment (P1-GCS5′) from the 5′-end of the P1 clone …

The rapid and robust induction of metallothioneins (MT)-I and II by a variety of inducers that
include heavy toxic metals, reactive oxygen species, and different types of stress provide a …