The gp91 phox homologue Nox1 produces H 2 O 2, which induces cell growth,
transformation, and tumorigenicity. However, it has not been clear whether H 2 O 2 effects …

Parkinson's disease (PD) is a neurodegenerative syndrome for which at present no cure is
available; therapy consists mainly of amelioration of the symptoms with l-Dopa and/or …

Exposure of cells to a wide variety of chemoprotective compounds confers resistance to a
broad set of carcinogens. For a subset of the chemoprotective compounds, protection is …

γ-Glutamylcysteine synthetase (GCS), the rate-limiting enzyme in the de novo synthesis of
GSH, is a heterodimer, consisting of a catalytic (GCSh) and a regulatory subunit (GCSl). We …

Abstract NF-E2 related factor 2 (Nrf2) is a CNC/b-zip protein that regulates antioxidant
response element (ARE)-mediated expression, and antioxidant induction, of detoxifying …

Copper is an essential metal that is able to produce reactive oxygen species and to induce
intracellular oxidative stress. Several studies have examined the effects of excessive copper …

A variety of cardiovascular, neurological, and neoplastic conditions have been associated
with oxidative stress, ie, conditions under which levels of reactive oxygen species (ROS) are …

Forty-four novel tricycles containing nonenolizable cyano enones (TCEs) were designed
and synthesized on the basis of a semisynthetic pentacyclic triterpenoid, bardoxolone …

Transcriptional control of target genes by antioxidant/electrophile response elements has
been well described in peripheral tissues. Genes that are regulated by this mechanism …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS), marked by infiltration of monocyte-derived macrophages in the brain parenchyma …