Background Pain and substance use are frequently comorbid and have been shown to exert
bidirectional effects. Self-medication of pain and distress via substance use is common and …

Background In light of the increased rates of Prescription Opioid (PO) misuse and
associated mortality in several developed countries in recent years, efforts have been made …

We now appreciate that the mechanism of resolution depends on an active and time-
dependent biosynthetic shift from pro-inflammatory to pro-resolution mediators, the so-called …

Background: Levels of prescription opioid (PO) dispensing have been rising in Canada–also
in global comparison–since the mid-2000s, and are co-occurring with extensive PO-related …

Pain is an unpleasant sensory and emotional experience that affects every aspect of a
patient's life and which may be treated through different pharmacological and non …

Background Prescription opioid use at high doses or over extended periods of time is
associated with adverse outcomes, including dependency and abuse. The aim of this study …

Abstract Purpose of Review Opioid receptors are widely expressed in the human brain. A
number of features commonly associated with drug use disorder, such as difficulties in …

Background: Little is known regarding the rates and risk factors for long-term postoperative
opioid use among opioid-naïve patients undergoing elective shoulder surgery. Purpose: To …

Abstract Purpose of Review The purpose of the present systematic review is to provide a
current understanding of the mechanism of action and the evidence available to support …

A clinical conundrum can occur when a patient with active opioid use disorder (OUD) or at
elevated risk for the condition presents with cancer and related painful symptoms. Despite …