Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

One of the fundamental issues in RNA splicing research is represented by understanding
how the spliceosome can successfully define exons and introns in a huge variety of pre …

Spinal muscular atrophy (SMA), a prominent genetic disease of infant mortality, is caused by
low levels of survival motor neuron (SMN) protein owing to deletions or mutations of the …

Background Dysregulations in alternative splicing (AS) patterns have been associated with
many human diseases including cancer. In the present study, alterations to the global RNA …

While inflammation induced by Toll-like receptor (TLR) signaling is required to combat
infection, persistent inflammation can damage host tissues and contribute to a myriad of …

UHMK1, a serine/threonine kinase with a U2AF homology motif, is implicated in RNA
processing and protein phosphorylation. Increasing evidence has indicated its involvement …

Although a robust inflammatory response is needed to combat infection, this response must
ultimately be terminated to prevent chronic inflammation. One mechanism that terminates …

The serotonin 2C receptor regulates food uptake, and its activity is regulated by alternative
pre‐mRNA splicing. Alternative exon skipping is predicted to generate a truncated receptor …

AtCyp59 is a multidomain cyclophilin containing a peptidyl-prolyl cis/trans isomerase
(PPIase) domain and an evolutionarily highly conserved RRM domain. Deregulation of this …

Multiple human diseases including cancer have been associated with a dysregulation in
RNA splicing patterns. In the current study, modifications to the global RNA splicing …