Despite the ongoing fundamental controversy about the physiological function of sleep,
there is general consensus that sleep benefits neuronal plasticity, which ultimately supports …

Hippocampal cellular and molecular processes critical for memory consolidation are
affected by the amount and quality of sleep attained. Questions remain with regard to how …

Adenosinergic modulation in the PFC is recognized for its involvement in various behavioral
aspects including sleep homoeostasis, decision-making, spatial working memory and …

Despite the success of antiretroviral therapy in suppressing viral load, nearly half of the 37
million people infected with HIV experience cognitive and motor impairments, collectively …

Purpose: The adenosinergic system is known to exert an inhibitory affect in the brain, and as
such adenosine has been considered an endogenous anticonvulsant. Entorhinal cortex …

Previous studies suggest that adenosine A 1 receptors (A 1 R) modulate the processing of
pain. The aim of this study was to characterize the distribution of A 1 R in nociceptive tissues …

Exogenous adenosine produces potent synaptic inhibition in spinal substantia gelatinosa
(SG), a region involved in nociceptive and thermoreceptive mechanisms. To examine the …

Methods: A semi-rapid hippocampal kindling model was used to induce seizures in male
Wistar rats. Examination of the electrophysiological properties of CA1 pyramidal neurons of …

Adenosine exerts multiple effects on pain transmission in the peripheral nervous system.
This study was performed to use confocal microscopy to evaluate whether adenosine could …

Activation of adenosinergic system in epileptogenic conditions is an efficient endogenous
anticonvulsivant mechanism that protects against pharmacoresistant epilepsy. However its …