Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia
BJ Wouters, R Delwel - Blood, The Journal of the American …, 2016 - ashpublications.org
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is
a heterogeneous malignancy characterized by distinct genetic abnormalities. Recent …
a heterogeneous malignancy characterized by distinct genetic abnormalities. Recent …
Emerging therapeutic strategies for unmet need in neovascular age-related macular degeneration
Neovascular age-related macular degeneration (nAMD) is a major cause of visual
impairment and blindness. Anti-vascular endothelial growth factor (VEGF) agents, such as …
impairment and blindness. Anti-vascular endothelial growth factor (VEGF) agents, such as …
Regulation of the methylation and expression levels of the BMPR2 gene by SIN3a as a novel therapeutic mechanism in pulmonary arterial hypertension
M Bisserier, P Mathiyalagan, S Zhang, F Elmastour… - Circulation, 2021 - Am Heart Assoc
Background: Epigenetic mechanisms are critical in the pathogenesis of pulmonary arterial
hypertension (PAH). Previous studies have suggested that hypermethylation of the BMPR2 …
hypertension (PAH). Previous studies have suggested that hypermethylation of the BMPR2 …
Emerging EZH2 inhibitors and their application in lymphoma
JK Lue, JE Amengual - Current hematologic malignancy reports, 2018 - Springer
Abstract Purpose of Review Enhancer of Zeste Homolog 2 (EZH2) is histone
methyltransferase and catalyzes the methylation of histone 3 lysine 27, a mark of …
methyltransferase and catalyzes the methylation of histone 3 lysine 27, a mark of …
EZH2 in myeloid malignancies
J Rinke, A Chase, NCP Cross, A Hochhaus, T Ernst - Cells, 2020 - mdpi.com
Our understanding of the significance of epigenetic dysregulation in the pathogenesis of
myeloid malignancies has greatly advanced in the past decade. Enhancer of Zeste Homolog …
myeloid malignancies has greatly advanced in the past decade. Enhancer of Zeste Homolog …
Molecular therapy for acute myeloid leukaemia
CC Coombs, MS Tallman, RL Levine - Nature reviews Clinical oncology, 2016 - nature.com
Acute myeloid leukaemia (AML) is a heterogeneous disease that is, in general, associated
with a very poor prognosis. Multiple cytogenetic and molecular abnormalities that …
with a very poor prognosis. Multiple cytogenetic and molecular abnormalities that …
Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations
H Wu, H Zeng, A Dong, F Li, H He, G Senisterra… - PloS one, 2013 - journals.plos.org
Polycomb repressive complex 2 (PRC2) is an important regulator of cellular differentiation
and cell type identity. Overexpression or activating mutations of EZH2, the catalytic …
and cell type identity. Overexpression or activating mutations of EZH2, the catalytic …
Micro-RNA profiling of exosomes from marrow-derived mesenchymal stromal cells in patients with acute myeloid leukemia: implications in leukemogenesis
J Barrera-Ramirez, JR Lavoie, HB Maganti… - Stem cell reviews and …, 2017 - Springer
Gene regulatory networks in AML may be influenced by microRNAs (miRs) contained in
exosomes derived from bone marrow mesenchymal stromal cells (MSCs). We sequenced …
exosomes derived from bone marrow mesenchymal stromal cells (MSCs). We sequenced …
The epigenetic landscape of acute myeloid leukemia
E Conway O'Brien, S Prideaux… - Advances in …, 2014 - Wiley Online Library
Acute myeloid leukemia (AML) is a genetically heterogeneous disease. Certain cytogenetic
and molecular genetic mutations are recognized to have an impact on prognosis, leading to …
and molecular genetic mutations are recognized to have an impact on prognosis, leading to …
Long noncoding RNA LINC00707 sponges miR-370-3p to promote osteogenesis of human bone marrow-derived mesenchymal stem cells through upregulating …
B Jia, Z Wang, X Sun, J Chen, J Zhao, X Qiu - Stem Cell Research & …, 2019 - Springer
Background Human bone marrow-derived mesenchymal stem cells (HBMSCs) are
characterized by multiple differentiation potential and potent self-renewal ability, yet much …
characterized by multiple differentiation potential and potent self-renewal ability, yet much …