Immunogenic cell death (ICD) is a regulated form of cell death that induces the activation of
both innate and adaptive immune responses through the release of damage-associated …

Tumour microenvironment is a complex ecosystem in which myeloid cells are the most
abundant immune elements. This cell compartment is composed by different cell types …

Macrophages represent the most prevalent immune cells in the tumor micro-environment,
making them an appealing target for tumor immunotherapy. One of our previous studies …

Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with
few therapeutic options available. Despite immunotherapy has revolutionised cancer …

Hepatocellular carcinoma (HCC) is a malignancy with high morbidity and mortality but lacks
effective treatments thus far. Although the emergence of immune checkpoint inhibitors in …

Although enormous success has been obtained for dendritic cells (DCs)‐mediated antigen‐
specific T cells anticancer immunotherapy in the clinic, it still faces major challenging …

Pancreatic cancer (PC) is one of the most lethal forms of cancer, characterized by its
aggressiveness and metastatic potential. Despite significant improvements in PC treatment …

Toll-like receptors (TLRs) play an important role between innate and adaptive immunity as
one of the pattern recognition receptors (PRRs). Both immune cells and tumor cells express …

Although checkpoint inhibitors (CPIs) have changed the paradigm of cancer therapy, low
response rates and serious systemic adverse events remain challenging. In situ vaccine …

Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease. This is due to its
aggressive course, late diagnosis and its intrinsic drugs resistance. The complexity of the …