Liquid biopsies are increasingly used for cancer molecular profiling that enables a precision
oncology approach. Circulating extracellular nucleic acids (cell-free DNA; cfDNA) …

Stem cell research offers great promise for understanding basic mechanisms of human
development and differentiation, as well as the hope for new treatments for diseases such as …

The association of genetic variation with disease and drug response, and improvements in
nucleic acid technologies, have given great optimism for the impact of 'genomic medicine' …

There has been much progress in genomics in the ten years since a draft sequence of the
human genome was published. Opportunities for understanding health and disease are now …

Recent advances in next-generation sequencing technologies have brought a paradigm
shift in how medical researchers investigate both rare and common human disorders. The …

Personalized cancer medicine is based on increased knowledge of the cancer mutation
repertoire and availability of agents that target altered genes or pathways. Given advances …

If genomic studies are to be a clinically relevant and timely reflection of the relationship
between genetics and health status—whether for common or rare variants—cost-effective …

Advances in computing technology and bioinformatics mean that medical research is
increasingly characterized by large international consortia of researchers that are reliant on …

Medical research is increasingly becoming data-intensive; sensitive data are being re-used,
linked and analysed on an unprecedented scale. The current EU data protection law reform …

Funding bodies have recently introduced a requirement that data sharing must be a
consideration of all funding applications in genomics. As with all new developments this …