Regulated degradation plays a key role in setting the level of many factors that govern cell
cycle progression. In Drosophila, the largest subunit of the origin recognition complex …

Abstract Background Microtubule‐targeing agents (MTAs), such as paclitaxel (PTX) and
vincristine (VCR), kill cancer cells through activtion of the spindle assembly checkpoint …

Silkworm silk gland cells undergo endoreplicating cycle and rapid growth during the larval
period, and synthesize massive silk proteins for silk production. In this study, we …

MDC1 (NFBD1), a mediator of the cellular response to DNA damage, plays an important role
in checkpoint activation and DNA repair. Here we identified a cross-talk between the DNA …

Microtubule associated proteins are involved in regulation of microtubule dynamics. Its
mutation and dysregulation result in severe consequences such as mitotic block and …

T-STAR is one of three members of the SAM68 family of RNA-binding proteins that have
been shown to be involved in various gene expression pathways including the control of pre …

FZR1 is an anaphase-promoting complex (APC) activator best known for its role in the
mitotic cell cycle at M-phase exit, in G1, and in maintaining genome integrity. Previous …

The awareness of the important role that the surrounding tissue microenvironment and
stromal response play in the process of tumorigenesis has grown as a result of in vivo …

Fizzy-related 1 (FZR1) is an activator of the Anaphase promoting complex/cyclosome
(APC/C) and an important regulator of the mitotic cell division cycle. Using a germ-cell …

Metaphase II-arrested mouse eggs are stimulated to complete meiosis by sperm-induced
Ca2+ spiking. The Ca2+ signal causes activation of the E3 ligase anaphase-promoting …