It is predicted that Japan and European Union will soon experience appreciable decreases
in their populations due to persistently low total fertility rates (TFR) below replacement level …

Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

Testicular germ cell tumours are at the crossroads of developmental and neoplastic
processes. Their cause has not been fully elucidated but differences in incidences suggest …

Vitamin D is a versatile signalling molecule with a well-established role in the regulation of
calcium homeostasis and bone health. The spectrum of vitamin D target organs has …

Introduction: Increasing evidence suggests that endocrine-disrupting chemicals (EDCs)
contribute to male reproductive diseases and disorders. Purpose: To estimate the …

In the last decade, vitamin D has emerged as a pleiotropic molecule with a multitude of
autocrine, paracrine and endocrine functions, mediated by classical genomic as well as non …

Germ-cell tumours (GCTs) are derived from germ cells and occur most frequently in the
testes,. GCTs are histologically heterogeneous and distinctly curable with chemotherapy …

Testicular germ cell tumours (TGCTs) are the most frequent cancer type in young men and
originate from the common precursor germ cell neoplasia in situ (GCNIS). For decades …

The decline in semen quality has been the subject of an animated debate. A recent
prospective study now irrefutably shows a decline in semen quality in men from Finland, a …

The production of spermatozoa relies on a pool of spermatogonial stem cells (SSCs), formed
in infancy from the differentiation of their precursor cells, the gonocytes. Throughout adult …