Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain

MP Kelly - Cellular signalling, 2018 - Elsevier
Deficits in brain function that are associated with aging and age-related diseases benefit
very little from currently available therapies, suggesting a better understanding of the …

Ryanodine receptors: physiological function and deregulation in Alzheimer disease

D Del Prete, F Checler, M Chami - Molecular neurodegeneration, 2014 - Springer
Abstract Perturbed Endoplasmic Reticulum (ER) calcium (Ca 2+) homeostasis emerges as a
central player in Alzheimer disease (AD). Accordingly, different studies have reported …

Lactobacilli and bifidobacteria ameliorate memory and learning deficits and oxidative stress in β-amyloid (1–42) injected rats

S Athari Nik Azm, A Djazayeri, M Safa… - Applied Physiology …, 2018 - cdnsciencepub.com
The gastrointestinal microbiota affects brain function, including memory and learning. In this
study we investigated the effects of probiotics on memory and oxidative stress biomarkers in …

Methanolic Extract of Piper nigrum Fruits Improves Memory Impairment by Decreasing Brain Oxidative Stress in Amyloid Beta(1–42) Rat Model of Alzheimer's …

L Hritcu, JA Noumedem, O Cioanca… - Cellular and molecular …, 2014 - Springer
The present study analyzed the possible memory-enhancing and antioxidant proprieties of
the methanolic extract of Piper nigrum L. fruits (50 and 100 mg/kg, orally, for 21 days) in …

Cognitive-enhancing and antioxidant activities of inhaled coriander volatile oil in amyloid β (1–42) rat model of Alzheimer's disease

O Cioanca, L Hritcu, M Mihasan, M Hancianu - Physiology & behavior, 2013 - Elsevier
Coriandrum sativum L., commonly known as coriander and belonging to the Apiaceae family
is cultivated throughout the world for its nutritional value. In traditional medicine, coriander is …

The old second messenger cAMP teams up with novel cell death mechanisms: potential translational therapeutical benefit for Alzheimer's disease and Parkinson's …

T Zhang, MDA Luu, AM Dolga, ULM Eisel… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) and Parkinson's disease (PD) represent the most prevalent
neurodegenerative disorders severely impacting life expectancy and quality of life of millions …

Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor

R Bussiere, A Lacampagne, S Reiken, X Liu… - Journal of Biological …, 2017 - ASBMB
Alteration of ryanodine receptor (RyR)-mediated calcium (Ca 2+) signaling has been
reported in Alzheimer disease (AD) models. However, the molecular mechanisms …

Protective Effects of Baicalin on Aβ1–42-Induced Learning and Memory Deficit, Oxidative Stress, and Apoptosis in Rat

H Ding, H Wang, Y Zhao, D Sun, X Zhai - Cellular and molecular …, 2015 - Springer
The accumulation and deposition of β-amyloid peptide (Aβ) in senile plaques and cerebral
vasculature is believed to facilitate the progressive neurodegeneration that occurs in the …

PEGylated superparamagnetic iron oxide nanoparticles (SPIONs) ameliorate learning and memory deficit in a rat model of Alzheimer's disease: Potential participation …

M Sanati, S Aminyavari, F Khodagholi, MJ Hajipour… - Neurotoxicology, 2021 - Elsevier
The amyloid-beta (Aβ) fibrillation process seems to execute a principal role in the
neuropathology of Alzheimer's disease (AD). Accordingly, novel therapeutic plans have …

The neuroprotective effects of peracetylated chitosan oligosaccharides against β-amyloid-induced cognitive deficits in rats

C Hao, M Han, W Wang, C Yang, J Wang… - Marine life science & …, 2023 - Springer
Chitosan oligosaccharides (COSs) have been reported to possess a broad range of
activities such as antitumor, antioxidant and neuroprotective activities. In this study, the …