Given that hypoxia is a persistent physiological feature of many different solid tumors and a
key driver for cancer malignancy, it is thought to be a major target in cancer treatment …

Telomeres, also known as the “protective caps” of our chromosomes, shorten with each cell
cycle due to the end replication problem. This process, termed telomere attrition, is …

Simple Summary The indolent nature of some cancers makes early detection challenging,
as such significant effort is placed on identifying circulating cancer biomarkers using …

Cancer is a heterogeneous disease with multifaceted drug resistance mechanisms (eg,
tumour microenvironment [TME], tumour heterogeneity, and immune evasion). Natural …

In this review, we highlight the similarities and key distinctions between replicative and
stress-evoked senescence. We discuss how cellular senescence acts as a key phenotype in …

Telomeres are nucleoprotein complexes that cap the ends of eukaryotic linear
chromosomes. Telomeric DNA is bound by shelterin protein complex to prevent telomeric …

Objective CD147 is an important glycoprotein that participates in the progression of diverse
cancers. This study aims to explore the specific function of CD147 in lung adenocarcinoma …

Introduction Monitoring the response after treatment of liver cancer and timely adjusting the
treatment strategy are crucial to improve the survival rate of liver cancer. At present, the …

Membrane-bound transcription factors (MTFs) have been observed in many types of
organisms, such as plants, animals and microorganisms. However, the routes of MTF …

Background Membranous nephropathy (MN) is an autoimmune disease and represents the
most prevalent type of renal pathology in adult patients afflicted with nephrotic syndrome …