The non-thyroidal illness syndrome (NTIS) was first reported in the 1970s as a remarkable
ensemble of changes in serum TH (TH) concentrations occurring in probably any severe …

Patients in the intensive care unit (ICU) typically present with decreased concentrations of
plasma tri-iodothyronine, low thyroxine, and normal range or slightly decreased …

Background: A number of recent advances in our understanding of thyroid physiology may
shed light on why some patients feel unwell while taking levothyroxine monotherapy. The …

Objective: To improve clinical outcome and to determine new treatment options, we studied
the pathophysiologic response postburn in a large prospective, single center, clinical trial …

Coronavirus disease 2019 (COVID-19) was characterized as a pandemic in March, 2020 by
the World Health Organization. COVID-19 is a respiratory syndrome that can progress to …

Thyroid hormones (TH) are crucial for growth and development and play an important role in
energy homeostasis. Although serum TH levels are relatively constant in the physiological …

The metabolic support of the critically ill patient is a relatively new target of active research
and little is as yet known about the effects of critical illness on metabolism. The nonthyroidal …

This article briefly summarizes thyroid function alterations generally seen in the euthyroid
sick syndrome, provides an overview of specific thyroidal adaptations during several clinical …

Thyroid hormone is essential for the normal function of virtually all tissues. The
iodothyronine deiodinases catalyze the removal of an iodine residue from the pro-hormone …

This paper provides the reader with an overview of our current knowledge of hypothalamic‐
pituitary‐thyroid feedback from a cybernetic standpoint. Over the past decades we have …