An understanding of the epigenetic mechanisms involved in sperm production and their
impact on the differentiating embryo is essential if we are to optimize fertilization and …

DNA methylation undergoes drastic fluctuation during early mammalian embryogenesis.
The dynamics of global DNA methylation in bovine embryos, however, have mostly been …

Imprinting control regions are differentially methylated in a parent-of-origin-dependent
manner and this methylation state is inherited through the germline. These regions control …

DNA methylation is an epigenetic form of gene regulation that is universally important
throughout the life course, especially during in utero and postnatal development. DNA …

To mimic post-ovulatory ageing, we have extended the in vitro maturation (IVM) phase to 48
h and examined effects on (i) developmental potential,(ii) expression of a panel of …

Although more than 100 imprinted genes have already been identified in the mouse and
human genomes, little is known about genomic imprinting in cattle. For a better …

Associations between abnormal methylation of spermatozoan DNA with male infertility have
been sought in recent years to identify a molecular explanation of differential spermatozoan …

Somatic cell nuclear transfer (SCNT) is commercially used despite incomplete nuclear
reprogramming of the somatic cell nucleus by the enucleated oocyte compromising its …

Epigenetic changes are critical for the acquisition of developmental potential by oocytes and
embryos, yet these changes may be sensitive to maternal ageing. Here, we investigated the …

Genomic imprinting is the preferential expression of one of two alleles of a gene in the
offspring based on parental origin. The number of experimentally confirmed imprinted genes …