Inhalation drug delivery in combating pulmonary infections: Advances and challenges

P Kumbhar, J Kaur, G De Rubis, KR Paudel… - Journal of Drug Delivery …, 2023 - Elsevier
Pulmonary infections (PIs) are contributing as a significant cause of mortality across the
world. The clinical applications of a variety of therapeutics approved for PIs have been …

Liposomal drug delivery to manage nontuberculous mycobacterial pulmonary disease and other chronic lung infections

JD Chalmers, J van Ingen… - European …, 2021 - Eur Respiratory Soc
Nontuberculous mycobacterial (NTM) pulmonary disease is a chronic respiratory infection
associated with declining lung function, radiological deterioration and significantly increased …

A metagenomic-based method to study hospital air dust resistome

X Li, Z Wu, C Dang, M Zhang, B Zhao, Z Cheng… - Chemical engineering …, 2021 - Elsevier
As a symbol of the defense mechanisms that bacteria have evolved over time, the genes that
make bacteria resist antibiotics are overwhelmingly present in the environment. Currently …

Approach to the Treatment of Patients with Serious Multidrug‐Resistant Pseudomonas aeruginosa Infections

JN O'Donnell, MR Bidell… - … : The Journal of Human …, 2020 - Wiley Online Library
Multidrug resistance (MDR) among Pseudomonas aeruginosa (PSA) isolates presents a
significant clinical challenge and can substantially complicate the approach to selection of …

[HTML][HTML] Advances in the cystic fibrosis drug development pipeline

C Esposito, M Kamper, J Trentacoste, S Galvin… - Life, 2023 - mdpi.com
Cystic fibrosis is a genetic disease that results in progressive multi-organ manifestations with
predominance in the respiratory and gastrointestinal systems. The significant morbidity and …

High-flow oxygen therapy and other inhaled therapies in intensive care units

SD Levy, JW Alladina, KA Hibbert, RS Harris, EK Bajwa… - The Lancet, 2016 - thelancet.com
In this Series paper, we review the current evidence for the use of high-flow oxygen therapy,
inhaled gases, and aerosols in the care of critically ill patients. The available evidence …

Surfactant-induced Marangoni transport of lipids and therapeutics within the lung

AZ Stetten, SV Iasella, TE Corcoran, S Garoff… - Current opinion in …, 2018 - Elsevier
Understanding the fundamentals of surface transport on thin viscous films has important
application in pulmonary drug delivery. The human lung contains a large-area interface …

Nebulization as a tool for photosensitizer delivery to the respiratory tract

G Kassab, MC Geralde, NM Inada… - Journal of …, 2019 - Wiley Online Library
To this day, any photosensitizers for the photodynamic treatment of pulmonary illnesses
have been administered intravenously. There is, however, an intrinsic difficulty in reaching …

[HTML][HTML] A breath of fresh air in the fog of antimicrobial resistance: inhaled polymyxins for gram-negative pneumonia

M Biagi, D Butler, X Tan, S Qasmieh, E Wenzler - Antibiotics, 2019 - mdpi.com
Despite advancements in therapy, pneumonia remains the leading cause of death due to
infectious diseases. Novel treatment strategies are desperately needed to optimize the …

[HTML][HTML] The future of inhalation therapy in chronic obstructive pulmonary disease

M Cazzola, J Ora, L Calzetta, P Rogliani… - Current Research in …, 2022 - Elsevier
The inhaled route is critical for the administration of drugs to treat patients suffering from
COPD, but there is still an unmet need for new and innovative inhalers to address some …