Two-component systems (TCS) regulate diverse processes such as virulence, stress
responses, metabolism and antibiotic resistance in bacteria but are absent in humans …

Background and Objectives: The study of clinical pharmacokinetics of inhaled antivirals is
particularly important as it helps one to understand the therapeutic efficacy of these drugs …

Background Bronchiectasis is a chronic inflammatory disease characterised by a recurrent
cycle of respiratory bacterial infections associated with cough, sputum production and …

Background Previous studies have questioned the efficacy and safety of intravenous
combined with aerosolised (IV+ AS) polymyxin versus intravenous (IV) polymyxin alone in …

Mechanical ventilation is a well-established and commonly employed modality of treatment
for critically ill patients in the ICU. Pneumonia is a frequent complication in mechanically …

Aerosol inhalation delivery of ceftriaxone in mice was investigated. An ultrasonic nebulizer
within the ranges of mean particle diameter 0.5–1.5 μm and mass concentration 0.01–0.6 …

Background: Secondary lung infections are the primary cause of morbidity associated with
cystic fibrosis lung disease. Aerosolized antibiotic inhalation is potentially advantageous but …

Airway obstruction with chronic inflammation and infection are major contributors to the lung
damage and mortality of cystic fibrosis (CF). A better understanding of the congested milieu …

Introduction: Available parenteral and oral administration of antimicrobial agents (AMAs) in
respiratory infections often show less penetration into the lung parenchyma. Due to …

Aims and objectives This study aimed to determine the knowledge and current practices of
ICU nurses regarding aerosol therapy for patients with invasive mechanical ventilation in …