The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

The ubiquitin/proteasome system is a primary conduit for selective intracellular protein
degradation. Since its discovery over 30 years ago, this highly regulated system continues to …

Aims Remote ischemic preconditioning (RIPC) of a limb is a clinically feasible strategy to
protect against ischemia–reperfusion injury after stroke. However, the mechanism …

Protein ubiquitination is a critical regulator of cellular homeostasis. Aberrations in the
addition or removal of ubiquitin can result in the development of cancer and key components …

Remote limb ischemic preconditioning (RIPC) is a clinically feasible strategy to protect
against ischemia/reperfusion injury, but the knowledge concerning the mechanism …

Simple Summary Head and neck cancer is the sixth most common cancer worldwide and
typically caused by smoking and alcohol consumption, or infection with Human …

NF-κB transcription factors are major drivers of tumor initiation and progression. NF-κB
signaling is constitutively activated by genetic alterations or environmental signals in many …

The ubiquitin proteasome system (UPS) plays an important role in regulating numerous
cellular processes, and a dysfunctional UPS is thought to contribute to motor neuron …

Aims CD1d is a member of the cluster of differentiation 1 (CD1) family of glycoproteins
expressed on the surface of various antigen-presenting cells, which is recognized by natural …

Background and Purpose Hydrogen sulfide (H2S) plays important roles as a gasotransmitter
in pathologies. Increased expression of the E3 ubiquitin ligase, muscle RING finger‐1 …