Phenotypic signatures of genetic frontotemporal dementia : Current Opinion in Neurology
Phenotypic signatures of genetic frontotemporal dementia : Current Opinion in Neurology Log in …

Neurodegenerative diseases are a large group of neurological disorders with diverse
etiological and pathological phenomena. However, current therapeutics rely mostly on …

Frontotemporal dementia (FTD) is a genetically and pathologically heterogeneous disorder
characterized by personality changes, language impairment, and deficits of executive …

Molecular imaging has proven to be a powerful tool for investigation of parkinsonian
disorders. One current challenge is to identify biomarkers of early changes that may predict …

Highlights•GPCRs are implicated in the pathophysiology of various neurodegenerative
diseases.•Currently available therapies do not cure the discussed neurodegenerative …

Genetic forms of frontotemporal dementia are most commonly due to mutations in three
genes, C9orf72, GRN or MAPT, with presymptomatic carriers from families representing …

Objective: To specify the presenting symptoms and clinical course of patients with
frontotemporal dementia (FTD) and chromosome 9 open reading frame 72 (C9ORF72) …

This paper summarizes the body of literature about early-onset dementia (EOD) that led to
recommendations from the Fourth Canadian Consensus Conference on the Diagnosis and …

Frontotemporal dementia is commonly associated with parkinsonism in several sporadic (ie,
progressive supranuclear palsy, corticobasal degeneration) and familial neurodegenerative …

Progranulin (PGRN) is a widely expressed protein with diverse biological functions. We
generated a transgenic mouse overexpressing PGRN and found significantly elevated …